학술논문
Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring : population based cohort study
Document Type
research-article
Author
Source
BMJ: British Medical Journal,
Subject
Language
English
ISSN
09598138
17561833
17561833
Abstract
To assess the potential association between prenatal use of antidepressants and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring.
Population based cohort study.
Data from the Hong Kong population based electronic medical records on the Clinical Data Analysis and Reporting System.
190 618 children born in Hong Kong public hospitals between January 2001 and December 2009 and followed-up to December 2015.
Hazard ratio of maternal antidepressant use during pregnancy and ADHD in children aged 6 to 14 years, with an average follow-up time of 9.3 years (range 7.4-11.0 years).
Among 190 618 children, 1252 had a mother who used prenatal antidepressants. 5659 children (3.0%) were given a diagnosis of ADHD or received treatment for ADHD. The crude hazard ratio of maternal antidepressant use during pregnancy was 2.26 (P
The findings suggest that the association between prenatal use of antidepressants and risk of ADHD in offspring can be partially explained by confounding by indication of antidepressants. If there is a causal association, the size of the effect is probably smaller than that reported previously.
Population based cohort study.
Data from the Hong Kong population based electronic medical records on the Clinical Data Analysis and Reporting System.
190 618 children born in Hong Kong public hospitals between January 2001 and December 2009 and followed-up to December 2015.
Hazard ratio of maternal antidepressant use during pregnancy and ADHD in children aged 6 to 14 years, with an average follow-up time of 9.3 years (range 7.4-11.0 years).
Among 190 618 children, 1252 had a mother who used prenatal antidepressants. 5659 children (3.0%) were given a diagnosis of ADHD or received treatment for ADHD. The crude hazard ratio of maternal antidepressant use during pregnancy was 2.26 (P
The findings suggest that the association between prenatal use of antidepressants and risk of ADHD in offspring can be partially explained by confounding by indication of antidepressants. If there is a causal association, the size of the effect is probably smaller than that reported previously.