부산대학교 도서관

Prolonged treatment of mice, starting at birth, with rabbit anti-mouse μ -chain antibodies resulted in the elimination of immunoglobulin-bearing B cells in these animals. The ability of these animals to elicit antigen-specific delayed-type hypersensitivity or cytotoxic T-cell responses to azobenzenearsonate-coupled spleen cells was not impaired. The effect of anti-μ treatment on the restriction by immunoglobulin heavy-chain genes (Igh) of suppressor T cells was investigated. We found that first-order suppressor T-cell factor (TsF 1 ) obtained from anti-μ treated animals expresses an Igh restriction pattern distinct from that observed with TsF 1 from normal untreated mice. Furthermore, TsF 1 prepared from anti-μ treated animals did not express the major crossreactive idiotypic determinants normally present in TsF 1 . The significance of these findings in relation to the role of immunoglobulin on the T-cell repertoire is discussed.