학술논문
Thermolabile Methylenetetrahydrofolate Reductase Polymorphism (C677T) and Total Homocysteine Concentration Among African-American and White Women
Document Type
research-article
Author
Giles, Wayne H.; Kittner, Steven J.; Ou, Chin-Yih; Croft, Janet B.; Brown, Vicki; Buchholz, David W.; Earley, Christopher J.; Feeser, Barbara R.; Johnson, Constance J.; Macko, Richard F.; McCarter, Robert J.; Price, Thomas R.; Sloan, Michael A.; Stern, Barney J.; Wityk, Robert J.; Wozniak, Marcella A.; Stolley, Paul D.
Source
Ethnicity & Disease, 1998 Apr 01. 8(2), 149-157.
Subject
Language
English
ISSN
1049510X
19450826
19450826
Abstract
A polymorphism associated with a thermolabile variant (C677T) of the enzyme methylenetetrahydrofolate reductase has been associated with both elevated total homocysteine (tHcy) levels and risk for cardiovascular disease. Data from the Stroke Prevention in Young Women Study were used to determine the prevalence of the C677T genotype and to assess whether environmental factors modified the association between genotype and tHcy concentration. The C677T genotype prevalence was 80% –/–, 20% +/–, and 0% +/+ among 46 African-American women; and 39% –/–, 53% +/–, and 8% +/+ among 77 white women (P