학술논문
Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse
Document Type
research-article
Author
Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team; Wade, C. M.; Giulotto, E.; Sigurdsson, S.; Zoli, M.; Gnerre, S.; Imsland, F.; Lear, T. L.; Adelson, D. L.; Bailey, E.; Bellone, R. R.; Blöcker, H.; Distl, O.; Edgar, R. C.; Garber, M.; Leeb, T.; Mauceli, E.; MacLeod, J. N.; Penedo, M. C. T.; Raison, J. M.; Sharpe, T.; Vogel, J.; Andersson, L.; Antczak, D. F.; Biagi, T.; Binns, M. M.; Chowdhary, B. P.; Coleman, S. J.; Valle, G. Delia; Fryc, S.; Guérin, G.; Hasegawa, T.; Hill, E. W.; Jurka, J.; Kiialainen, A.; Lindgren, G.; Liu, J.; Magnani, E.; Mickelson, J. R.; Murray, J.; Nergadze, S. G.; Onofrio, R.; Pedroni, S.; Piras, M. F.; Raudsepp, T.; Rocchi, M.; Røed, K. H.; Ryder, O. A.; Searle, S.; Skow, L.; Swinburne, J. E.; Syvänen, A. C.; Tozaki, T.; Valberg, S. J.; Vaudin, M.; White, J. R.; Zody, M. C.; Lander, E. S.; Lindblad-Toh, K.
Source
Science, 2009 Nov 01. 326(5954), 865-867.
Subject
Language
English
ISSN
00368075
10959203
10959203
Abstract
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chrompsomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.