학술논문
Maternal Virus Load during Pregnancy and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1: The French Perinatal Cohort Studies
Document Type
research-article
Author
Source
The Journal of Infectious Diseases, 1997 Jan 01. 175(1), 172-175.
Subject
Language
English
ISSN
00221899
Abstract
Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% ± 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with 10,000 copies/mL (P < .02). Maternal virus load appears strongly related to HIV transmission to the child.