학술논문
The Complete Genome Sequence of Chromobacterium violaceum Reveals Remarkable and Exploitable Bacterial Adaptability
Document Type
research-article
Author
de Almeida, Darcy F.; Hungria, Mariangela; Guimarães, Claudia Teixeira; Antônio, Regina Vasconcellos; Almeida, Francisca Cunha; de Almeida, Rosana; Alves-Gomes, José Antonio; Andrade, Elizabeth Mazoni; Araripe, Julia; Astolfi-Filho, Spartaco; Azevedo, Vasco; Baptista, Alessandra Jorge; Beló, André; van den Berg, Cássio; Bogo, Maurício; Bonatto, Sandro; Bordignon, Juliano; Brigido, Marcelo Macedo; Brito, Cristiana Alves; Brocchi, Marcelo; Burity, Helio Almeida; Camargo, Anamaria Aranha; Carneiro, Newton Portilho; Carraro, Dirce Maria; Cavada, Benildo Sousa; Creczynski-Pasa, Tânia Beatriz; da Cunha-Junior, Nivaldo Costa; Fagundes, Nelson; Falcão, Clarissa Lima; Fantinatti, Fabiana; Farias, Izeni Pires; Ferrari, Lilian Pereira; Ferro, Jesus Aparecido; Franco, Gloria Regina; Furlan, Luiz Roberto; Gazzinelli, Ricardo Tostes; Gomes, Eliane Aparecida; Gonçalves, Pablo Rodrigues; Grangeiro, Thalles Barbosa; Grattapaglia, Dario; Grisard, Edmundo Carlos; Hanna, Ebert Seixas; Jardim, Sílvia Neto; Laurino, Jomar; Manfio, Gilson Paulo; Maranhão, Andrea Queiroz; Martins, Wellington Santos; Nicolás, Marisa Fabiana; Oliveira, Jaquelline Germano; Oliveira, Sergio Costa; Parente, Juliana Alves; Pereira, José Odair; Pereira, Maristela; Potrich, Deise Porto; Ramalho-Neto, Cicero Eduardo; Rigo, Liu Um; Rondinelli, Edson; Santos, Fabrício R.; Seuanez, Hector N.; Silva, Denise Wanderlei; Silva, Rosane; Simon, Daniel; Souza, Emanuel Maltempi; Souza, Rangel Celso; Steindel, Mário; Teixeira, Santuza Ribeiro; Urmenyi, Turan; Vettore, André; Wassem, Roseli; Zaha, Arnaldo
Source
Proceedings of the National Academy of Sciences of the United States of America, 2003 Sep . 100(20), 11660-11665.
Subject
Language
English
ISSN
00278424
Abstract
Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.