학술논문
New insights into oxidative folding
Comment
Comment
Document Type
Author abstract
Report
Report
Author
Source
The Journal of Cell Biology. March 22, 2010, Vol. 188 Issue 6, p757, 2 p.
Subject
Language
English
ISSN
0021-9525
Abstract
The oxidoreductase ERO1 (endoplasmic reticulum [ER] oxidoreductin 1) is thought to be crucial for disulfide bond formation in the ER. In this issue, Zito et al. (2010. J. Cell Biol. doi:10.1083/jcb.200911086) examine the division of labor between the two mammalian isoforms of ERO1 (ERO1-[alpha] and -[beta]) in oxidative folding. Their analysis reveals a selective role for ERO1-[beta] in insulin production and a surprisingly minor contribution for either ERO1 isoform on immunoglobulin folding and secretion. doi/10.1083/jcb.201002114