부산대학교 도서관

Keywords: brain health; diffusion magnetic resonance imagingfrailty; physical capacity BACKGROUND Cross-sectional associations have been found between frail individuals and worse white matter (WM) integrity. However, the prospective association between WM integrity and frailty is still unclear. Our objectives were to measure associations between WM integrity using diffusion tensor imaging (DTI) and the 5-year worsening of frailty in community-dwelling older adults. DESIGN Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT). SETTING Thirteen memory centers in France and Monaco between 2008 and 2011. PARTICIPANTS Participants (mean age = 74.7[+ or -]3.9years) with no dementia at baseline who had functional magnetic resonance imaging performed as part of the MAPT study (n = 227). MEASUREMENTS Fractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) were acquired for 10 different brain regions. Frailty was assessed by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven time points for 5years. Mixed effect ordinal logistic regression model was used to assess the prospective association between DTI parameters (independent variables) and frailty (dependent variable). All the analyses were adjusted for age, sex, baseline total intracranial volume, and the presence of one of the following cardiovascular risk factors (hypertension, diabetes, and/or hypercholesterolemia). RESULTS A statistically significant association was found between the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) and worsening of frailty over 5years after adjusting for multiple comparisons. CONCLUSIONS This is the first study to show that WM integrity is associated with frailty in older adults. The mechanisms related to these results require further investigation. J Am Geriatr Soc 68:1050-1055, 2020 CAPTION(S): Supplementary Table S1: Over-Time Associations Between Fractional Anisotropy and Mean Diffusivity of Regions of Interest With Frailty. Supplementary Table S2: Over-Time Associations Between Axial Diffusivity and Radial Diffusivity of Regions of Interest With Frailty. Supplementary Table S3: Over-Time Associations Between Fast Deterioration of DTI Parameters and Frailty. Supplementary Table S4: Over-Time Associations Between Fast Deterioration of DTI Parameters and Frailty. Supplementary Table S5: Association Between WM Integrity of Different Brain Regions and Its Association With the Risk of Frailty Over 5Years, Adjusting for White Matter Lesions. Supplementary Table S6: Association Between WM Integrity of Different Brain Regions and Its Association With the Risk of Frailty Over 5Years, Adjusting for White Matter Lesions. Supplementary Table S7: Characteristics of the Participants With DTI Parameters Measured at Baseline and at 5Years and the Comparison With the Total Sample (n = 110). Byline: Mathieu Maltais, Philipe Souto Barreto, Lisa Perus, Jean-Francois Mangin, Antoine Grigis, Marie Chupin, Ali Bouyahia, Audrey Gabelle, Julien Delrieux, Yves Rolland, Bruno Vellas, Bruno Vellas, Sophie Guyonnet, Isabelle Carrie, Laureane Brigitte, Catherine Faisant, Francoise Lala, Julien Delrieu, Helene Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Sandrine Andrieu, Christelle Cantet, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Celine Caillaud, Pierre-Jean Ousset, Francoise Lala, Jean-Francois Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noelle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valerie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valerie Faure, Michael LiYungTong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Francoise Desclaux, Colette Blatge, Thierry Dantoine, Cecile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clement, Marie-Agnes Picat, Laurence Bernard-Bourzeix, Stephanie Willebois, Ileana Desormais, Noelle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gedeon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stephanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristelle Sudres, Nicolas Lebrun, Nadege Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurelia Romano, Lynda Touati, Cecilia Marelli, Cecile Pays, Philippe Robert, Franck Le Duff, Claire Gervais, Sebastien Gonfrier, Yannick Gasnier, Serge Bordes, Daniele Begorre, Christian Carpuat, Khaled Khales, Jean-Francois Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, Carole Dufouil, Stephane Lehericy, Marie Chupin, Jean-Francois Mangin, Ali Bouhayia, Michele Allard, Frederic Ricolfi, Dominique Dubois, Marie Paule Bonceour Martel, Francois Cotton, Alain Bonafe, Stephane Chanalet, Francoise Hugon, Fabrice Bonneville, Christophe Cognard, Francois Chollet, Pierre Payoux, Thierry Voisin, Julien Delrieu, Sophie Peiffer, Anne Hitzel, Michele Allard, Michel Zanca, Jacques Monteil, Jacques Darcourt, Laurent Molinier, Helene Derumeaux, Nadege Costa, Bertrand Perret, Claire Vinel, Sylvie Caspar-Bauguil