학술논문
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants
Document Type
Academic Journal
Author
McCallum, Matthew; Walls, Alexandra C.; Sprouse, Kaitlin R.; Bowen, John E.; Rosen, Laura E.; Dang, Ha V.; De Marco, Anna; Franko, Nicholas; Tilles, Sasha W.; Logue, Jennifer; Miranda, Marcos C.; Ahlrichs, Margaret; Carter, Lauren; Snell, Gyorgy; Pizzuto, Matteo Samuele; Chu, Helen Y.; Van Voorhis, Wesley C.; Corti, Davide; Veesler, David
Source
Science. December 24, 2021, Vol. 374 Issue 6575, p1621, 6 p.
Subject
Language
English
ISSN
0036-8075
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including the B.l.617.2 (Delta) variant of concern that is causing a new wave of infections and has become globally dominant. We show that these variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion. Mutations in the B.1.617.1 (Kappa) and Delta spike glycoproteins abrogate recognition by several monoclonal antibodies via alteration of key antigenic sites, including remodeling of the Delta ammo-terminal domain. The angiotensin-converting enzyme 2 binding affinities of the Kappa and Delta receptor binding domains are comparable to the Wuhan-Hu-1 isolate, whereas B.1.617.2+ (Delta+) exhibits markedly reduced affinity.