학술논문
National estimates of serum total 25-hydroxyvitamin D and metabolite concentrations measured by liquid chromatography-tandem mass spectrometry in the US population during 2007-2010
Document Type
Author abstract
Report
Report
Author
Source
The Journal of Nutrition. May, 2016, Vol. 146 Issue 5, p1051, 11 p.
Subject
Language
English
ISSN
0022-3166
Abstract
Background: The 2007-2010 NHANES provides the first US nationally representative serum 25-hydroxyvitamin D [25(OH)D] concentrations measured by standardized liquid chromatography-tandem mass spectrometry. Objective: We describe patterns for total 25(OH)D and individual metabolites in persons aged [greater than or equal to] 1 y stratified by race-ethnicity and grouped by demographic, intake, physiologic, and lifestyle variables. Methods: We measured 25-hydroxycholecalciferol [25(OH)[D.sub.3]], 25-hydroxyergocalciferol [25(OH)[D.sub.2]], and C3- epimer of 25(OH)[D.sub.3] [C3epi-25(OH)[D.sub.3] in serum samples (n = 15,652) from the 2007-2010 cross-sectional NHANES [total 25(OH)D = 25(OH)[D.sub.3] + 25(OH)[D.sub.2]]. Results: Concentrations (median, detection rate) of 25(OH)[D.sub.3] (63.6 nmol/L, 100%) and C3-epi-25(OH)[D.sub.3] (3.40 nmol/L, 86%) were generally detectable: 25(OH)[D.sub.2] was detectable in 19% of the population. Total 25(OH)D, 25(OH)[D.sub.3], and C3- epi-25(OH)[D.sub.3] displayed similar demographic patterns and were strongly correlated (Spearman's r > 0.70). Concentrations of 25(OH)[D.sub.2] (90th percentile) were much higher in persons aged [greater than or equal to] 60 y (17.3 nmol/L) than in younger age groups ([less than or equal to] 4.88 nmol/L). We noted significant race-ethnicity differences in mean total 25(OH)D [non-Hispanic blacks (NHBs), Hispanics, and non-Hispanic whites (NHWs): 46.6, 57.2, and 75.2 nmol/L, respectively] and in the prevalence of total 25(OH)D Conclusions: Race-ethnicity differences in the prevalence of low total 25(OH)D remained strong even after adjustment for season to account for the NHANES design imbalance between season, latitude, and race-ethnicity. The strong correlation between C3-epi-25(OH)[D.sub.3] and 25(OH)[D.sub.3] may be because the epimer is a metabolite of 25(OH)[D.sub.3] The presence of 25(OH)[D.sub.2] mainly in older persons is likely a result of high-dose prescription vitamin [D.sub.2]. Keywords: NHANES, 25-hydroxyvitamin [D.sub.3], 25-hydroxyvitamin [D.sub.2], C3-epimer of 25-hydroxyvitamin [D.sub.3], LC-MS/MS doi: 10.3945/jn.115.227728