부산대학교 도서관

Purpose To investigate the trend of seasonal variation of intraocular pressure (IOP) in patients with normal-tension glaucoma over a 20-year period by retrospectively analyzing the Kyoto Prefectural University of Medicine Glaucoma Registry database as real-world data. Design Retrospective cohort study. Methods Data points (n = 49,007) were extracted retrospectively from the medical records of 1774 patients with normal-tension glaucoma (665 male patients and 1109 female patients; mean [plus or minus] SD age was 59.8 [plus or minus] 14.4 years; and mean [plus or minus] SD observation period was 5.6 [plus or minus] 4.4 years) seen over the 20-year period. We first calculated the mean IOP from all available data of each month from January 1997 through December 2016. The data were then categorized into 5 groups of 4 consecutive years each (1997-2000, 2001-2004, 2005-2008, 2009-2012, and 2013-2016) and the mean IOP of each month within the group was calculated. Seasonal variations of IOP over the 20-year study period and in the 5 consecutive groups were then investigated via nonlinear multiple regression analysis. Results A continuous decrease of IOP was detected throughout the 20-year period (P < .001), with distinct seasonal variation. The annual mean [plus or minus] SD IOP was highest (13.9 [plus or minus] 2.7 mm Hg) in the oldest group (1997-2000), with a gradual decrease in each subsequent group, finally becoming lowest (12.3 [plus or minus] 2.7 mm Hg) in the most recent group (2013-2016) (P < .001), and all of them were accompanied by distinct seasonal variation (P < .001). Conclusions Based on the Kyoto Prefectural University of Medicine Glaucoma Registry real-world longitudinal data, our findings revealed a continuous decrease and distinct seasonal variation of IOP in patients with normal-tension glaucoma throughout the 20-year study period. Author Affiliation: (1) From the Departments of Ophthalmology, (Y.I., K.M., M.U., Y.M., K.I., Y.Y., C.S (2) Mathematics and Statistics in Medical Sciences, (K.Y.) (3) Genomic Medical Sciences (M.N., R.S., F.S., N.O., K.T.) (4) and Frontier Medical Science and Technology for Ophthalmology (S.K.) (5) Kyoto Prefectural University of Medicine, Kyoto, Japan (6) Oike-Ikeda Eye Clinic, Kyoto, Japan (Y.I., K.M.) (7) and Baptist Eye Institute, Kyoto, Japan (T.Y.) * Inquiries to Kazuhiko Mori, Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-8566, Japan. Article History: Received 21 May 2021; Revised 4 October 2021; Accepted 6 October 2021 (footnote) Supplemental Material available at AJO.com. Byline: YOKO IKEDA (1,5,6), KAZUHIKO MORI [kmori@koto.kpu-m.ac.jp] (1,5,6,*), MORIO UENO (1), KENGO YOSHII (2), MASAKAZU NAKANO (3), RYUICHI SATO (3), FUMIKO SATO (3), YUKO MARUYAMA (1), KOJIRO IMAI (1), NATSUE OMI (3), YUJI YAMAMOTO (1), TOSHIHIDE YAMASAKI (7), KEI TASHIRO (3), CHIE SOTOZONO (1), SHIGERU KINOSHITA (4)