학술논문

Simplified antibiotic regimens compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with clinical signs of possible serious bacterial infection when referral is not possible: a randomised, open-label, equivalence trial
Document Type
Academic Journal
Author
Source
The Lancet. May 2, 2015, Vol. 385 Issue 9979, p1767, 10 p.
Subject
Nigeria
Language
English
ISSN
0140-6736
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(14)62284-4 Byline: Antoinette Tshefu, Adrien Lokangaka, Serge Ngaima, Cyril Engmann, Fabian Esamai, Peter Gisore, Adejumoke Idowu Ayede, Adegoke Gbadegesin Falade, Ebunoluwa A Adejuyigbe, Chineme Henry Anyabolu, Robinson D Wammanda, Clara L Ejembi, William N Ogala, Lu Gram, Simon Cousens Abstract: WHO recommends hospital-based treatment for young infants aged 0-59 days with clinical signs of possible serious bacterial infection, but most families in resource-poor settings cannot accept referral. We aimed to assess whether use of simplified antibiotic regimens to treat young infants with clinical signs of severe infection was as efficacious as an injectable procaine benzylpenicillin-gentamicin combination for 7 days for situations in which hospital referral was not possible. Author Affiliation: (a) Department of Community Health, Kinshasa School of Public Health, Kinshasa, DR Congo (b) Departments of Pediatrics and Maternal Child Health, Schools of Medicine and Public Health, University of North Carolina, Chapel Hill, NC, USA (c) Department of Child Health and Paediatrics, School of Medicine, Moi University, Eldoret, Kenya (d) Department of Paediatrics, College of Medicine, University of Ibadan, and University College Hospital, Ibadan, Nigeria (e) Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria (f) Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria (g) Department of Community Medicine, Ahmadu Bello University Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria (h) Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK