학술논문
Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial
Document Type
Academic Journal
Author
Anderson, Craig S; Huang, Yining; Lindley, Richard I; Chen, Xiaoying; Arima, Hisatomi; Chen, Guofang; Li, Qiang; Billot, Laurent; Delcourt, Candice; Bath, Philip M; Broderick, Joseph P; Demchuk, Andrew M; Donnan, Geoffrey A; Durham, Alice C; Lavados, Pablo M; Lee, Tsong-Hai; Levi, Christopher; Martins, Sheila O; Olavarria, Veronica V; Pandian, Jeyaraj D; Parsons, Mark W; Pontes-Neto, Octavio M; Ricci, Stefano; Sato, Shoichiro; Sharma, Vijay K; Silva, Federico; Song, Lili; Thang, Nguyen H; Wardlaw, Joanna M; Wang, Ji-Guang; Wang, Xia; Woodward, Mark; Chalmers, John; Robinson, Thompson G; Anderson, Craig S.; Lindley, Richard I.; Bath, Philip M.; Broderick, Joseph P.; Demchuk, Andrew M.; Donnan, Geoffrey A.; Durham, Alice C.; Lavados, Pablo M.; Martins, Sheila O.; Olavarria, Veronica V.; Pandian, Jeyaraj D.; Parsons, Mark W.; Pontes-Neto, Octavio M.; Sharma, Vijay K.; Thang, Nguyen H.; Wardlaw, Joanna M.; Robinson, Thompson G.; Kim, Jong S.; Stapf, Christian; Simes, R. John; Hankey, Graeme J.; Sandercock, Peter; Bousser, Marie-Germaine; Wong, K.S. Lawrence; Scaria, Anish; Hirakawa, Yoichiro; Moullaali, Tom J.; Carcel, Cheryl; Gordon, Penny; Fuentes-Patarroyo, Sully X.; Benito, Dino; Chen, Ruiqi; Cao, Yongjun; Kunchok, Amy; Winters, Stephen; Coutts, Shelagh; Yoshimura, Sohei; You, Shoujiang; Yang, Jie; Wu, Guojun; Zhang, Shihong; Manning, Lisa; Mistri, Amit; Haunton, Victoria; Minhas, Jatinder; Malavera, Alejandra; Lim, Joyce; Liu, Leibo; Kumar, Namrata N.; Tay, Nicole; Jenson, Kerry; Richtering, Sarah; Tucker, Sharon; Knight, Elizabeth; Ivanova, Elizaveta; Thembani, Emma; Odgers, Elizabeth; Sanders, Elizabeth; Small, Sabrina; Vaghasiya, Ruchita; Armenis, Manuela; Donnelly, Paul; Baig, Merza A.; Blacklock, Nick; Naidu, Bala; Monaghan, Helen; Smith, Phillipa; Glass, Parisa; Bai, Xuejie; Li, Qiancheng; Zhu, Pingping; Kong, Liang; He, Ruihong; Zhao, He; Lv, Jiajie; Jia, Haijing; Xi, Zhen; Cong, Yuhan; Cui, Buliang; Deng, Hua; Guo, Ying; He, Lingyu; Jia, Ruolan; Li, Nan; Li, Wei; Liu, Mengxiao; Zhang, Meng; Xu, Ziwei; Zhang, Ting; Zhao, Yan; Gregory, Philip; In, Yunjeong; Kim, Su J.; Ahn, Jung E.; Kim, Sul H.; Hong, Young L.; Gonzalez-McCawley, Francisca; Martins, Magda C.O.; Portales, Bernardita; Wang, Ching-Yi; Ryu, Shan-Jen; Aujla, Hardeep; Lewin, Sue; Kumar, Tracy; Barrows, Sara; Ebraimo, Ahtasam; Uyen, Hong H.; Giang, Nguyen A.; Linh, Le T.M.; An, Le T.T.; Phuong, Do M.; Ngoc, Pham V.B.; Hang, Nguyen M.; Tran, Nguyen T.B.; Hien, Ha T.T.; Yen, Mai B.; Tram, Ngo T.B.; Truc, Tran T.T.; Hoa, Nguyen A.; Thuan, Nguyen T.B.; Oanh, Ha T.K.; Arora, Deepti; Verma, Shweta J.; Krause, M.; Priglinger, M.; Day, S.; Jala, S.; Davies, L.; Ray, E.; Celestino, S.; Law, L.Y.; Wijeratne, T.; Ng, G.; Nagao, K.; Weiss, G.; Titton, N.; Batista, C.; Zan, D.; Carbonera, L.; Ferreira, K.; Castro, R.; Martins Filho, R.K.; Carvalho, M.; Libardi, M.; Martins, G.; Fagundes, D.; Baron, G.; Boehringer, A.; Barbosa, J.; Bazan, R.; Braga, G.; Luvizutto, G.; Ribeiro, P.; Winckler, F.; Moro, C.; Longo, A.; Liberato, R.; Barbosa, R.; Magalhaes, P.; Portal, M.; Martin, K.; Souza, A.; Cuervo, D.; Perin, D.; Marques, L.; Oliveira, F.; Battaglini, M.; Lourenco, F.; Silva, G.; Duarte, L.; Alves, M.; Sousa, J.; Uhehara, M.; Brunser, A.; Mazzon, E.; Spencer, M.; Acosta, I.; Rojo, A.; Rivas, R.; Klapp, C.; Carvallo, L.; Carvallo, P.; Mansilla, E.; Flores, J.; Alvarado, M.; Herrera, A.; Reyes, C.; Jurado, F.; Bustamante, G.; Bravo, L.; Matamala, J.M.; Guerrero, R.; Zhou, S.; Ping, L.; Liu, W.; Liu, L.; Tian, Y.; Xu, H.; Wang, J.; Wang, L.; Zhen, Z.; Zhang, J.; Yan, M.; Zhang, Q.; Tao, X.; Liu, C.; Shi, J.; Zhang, X.; Tai, L.; Xu, L.; Lu, H.; Nie, H.; Li, X.; Zhou, J.; Liu, Y.; Gong, P.; Zhao, H.; Li, R.; Wang, X.; Chen, Q.; Li, Y.; Wu, L.; Jia, L.; Guo, X.; Chen, G.; Lin, B.; Zhu, W.; Yang, K.; Zhang, Z.; Xie, C.; Wu, D.; Wang, Y.; Liu, D.; Liu, Z.; Liang, L.; Cao, Q.; Xia, J.; Weng, Y.; Li, J.; Xu, T.; Geng, D.; Yan, X.; Wang, D.; Zhao, N.; Tang, Z.; Yin, W.; Wang, S.; Huang, W.; Yang, Y.; Song, A.; Hao, Y.; Zhang, A.; Qiao, B.; Yang, J.; Yan, H.; Wei, X.; Tao, Z.; Liu, H.; Lv, Y.; Yang, H.; Han, L.; Mao, X.; Ge, L.; Zhang, Y.; He, S.; Jiang, J.; Wu, W.; Wang, H.; Yang, L.; Tang, Y.; Sun, H.; Li, F.; Li, G.; Sun, Y.; Zhang, H.; Wu, Y.; Huang, L.; Geng, C.; Jin, Z.; Zhu, J.; Zhang, F.; Zheng, R.; Shen, H.; Liu, F.; Chen, C.; Chen, S.; Zhou, L.; Hu, B.; Zou, Z.; Liu, J.; Chang, X.; Zhang, S.; Huang, Q.; Liu, X.; Liu, S.; He, W.; Feng, J.; Li, L.; Chen, X.; Zhuang, X.; Zheng, W.; Lai, Y.; Zhou, Y.; Duan, H.; Yang, Q.; Du, J.; Lin, Q; Xu, E.; Zhan, L.; Wu, J.; Feng, X.; Wei, C.; He, J.; Wang, B.; Li, W; Chen, P; Guo, F; Dai, H; Dai, M; Zeng, X.; Chen, B.; Long, F.; Su, Q.; Bao, B.; Wu, T.; Wu, X.; Shao, Y.; Li, S.; Xu, Y.; Castellanos, J.A.; Munoz-Collazos, M.; Solano, E.; Leung, W.H.T.; Sureshbabu, S.; Sharma, S.N.; George, S.; Shekhar, S.; Singla, S.; Saini, L.; Sunita, -; Kate, M.; Sarvotham, R.; William, A.G.; Deepak, A.; BK, M.; Benny, R.; Bolegave, V.; Basle, M.; Gore, S.; George, P.; Kumaravelu, S.; Rahamath, S.; Raj, P.G.; Devi, A.R.; Sharma, A.; Prajapati, J.; Parmar, M.; Patel, D.; Panchal, T.; Gorthi, S.P.; Prabhu, V.; Prabhu, A.; Chandran, V.; Chatterjee, A.; Nair, R.; Nambiar, V.K.; TS, D.; TP, S.; Ajai, V.; Paul, S.; Natarajan, P.C.; Chittibabu, D.; Borah, N.C.; Ghose, M.; Choudhury, N.; Gohain, P.; Kalita, K.; Duberkar, D.; Pawar, N.; Bhaviskar, R.; Caterbi, E.; Cenciarelli, S.; Condurso, R.; Gallinella, E.; Greco, L.; Marando, C.; Mastrocola, S.; Mattioni, A.; Sacchini, E.; Sicilia, I.; Gallina, A.; Giannandrea, D.; Marsili, E.; Mazzoli, T.; Padiglioni, C.; Corea, F.; Guidubaldi, A.; Micheli, S.; Barbi, M.; Kim, J.; Song, H.J.; Jeong, H.S.; Lim, J.G.; Park, S.M.; Lee, K.B.; Hwang, H.W.; Kwon, S.U.; Kang, D.W.; Kim, Y.J.; Kim, B.J.; Park, J.M.; Kang, K.; Kim, B.; Kwon, O.; Kim, Y.W.; Lee, J.J.; Hwang, Y.H.; Kwon, H.S.; Koo, J.; Lee, K.; Kim, T.; Ahn, A.; Rha, J.H.; Park, H.K.; Yoon, C.W.; Chan, B.; Teoh, H.L.; Paliwal, P.; Wong, L.Y.J.; Chen, J.T.; De Silva, D.A.; Chang, H.M.; Fabiana, N.; Marti, J.; Delgado, R.; Martinez, A.; Prats, L.; Camps, P.; Liou, C.W.; Tan, T.Y.; Liu, C.F.; Cheng, H.H.; Po, H.L.; Lin, Y.J.; Chou, C.L.; Lin, C.H.; Yen, C.C.; Chang, Y.T.; Hsu, Y.T.; Lee, J.D.; Lee, M.; Huang, Y.C.; Wu, C.Y.; Suwanwela, N.C.; Chutinet, A.; Likitjaroen, Y.; Roongpiboonsopit, D.; Charnwut, S.; Dyker, A.; Hossain, M.; Muddegowda, G.K.; Sanyal, R.; Roffe, C.; Natarajan, I.; Finney, K.; Sztriha, L.; Teo, J.; Chan, F.K.; Lim, J.; Chitando, B.; Clarke, B.; Patel, B.; Khan, U.; Ghatala, R.; Trippier, S.; Kalra, L.; Manawadu, D.; Sikondari, N.; Aeron-Thomas, J.; Sunman, W.; Wilkes, G.; Richardson, C.; Buch, A.; Jackson, B.; Halse, O.; Mashate, S.; Wilding, P.; Nguyen, V.; Qadiri, M.R.; Rashed, K.; Board, S.; Buckley, C.; Smith, C.; James, M.; Keenan, S.; Bouring, A.; England, T.; Donnelly, R.; Scott, J.; Maddula, M.; Beavan, J.; Perry, R.; Francia, N.; Watchhurst, C.; Banaras, A.; Ashton, A.; Mistri, A.; Musarrat, K.; Eveson, D.; Kallingal, J.; Perez, J.; Harrison, L.; Marsden, T.; Furnace, J.; Clarke, R.; Reid, J.; Warburton, E.; Macleod, M.J.; Mitchell, J.; Day, D.; Church, N.; Amis, E.; Price, C.; Rodgers, H.; Whiting, R.; Hussain, M.; Harvey, M.; Brown, S.; Foot, J.; Tryambake, D.; Broughton, D.; Bergin, A.; Annamalai, A.; Dixon, L.; Weir, N.; Blank, C.; Harkness, K.; Ali, A.; Richards, E.; Stocks, K.; Bruce, D.W.; Wani, M.; Anjum, T.; Krishnan, M.; Nguyen Huy, T.; Le Tuan, A. Truong; Cam, L. Dam Thi; Kim, T. Ngo Thi; Nguyen, B. Pham; Dat, A. Nguyen; Van, C. Nguyen; Duy, T. Mai; Viet, P. Dao; Tien, D. Nguyen; Van, T. Vo; Le Kim, K.; Ngoc, T. Bui; Le Thanh, T. Tran; Hoanh, S. Nguyen; Phuoc, S. Pham; Van, T. Tran; Thi, B. Doan; Thu, H. Nguyen Thi; Duy, M. Nguyen; Van, D. Ngo
Source
The Lancet. March 2, 2019, Vol. 393 Issue 10174, 877
Subject
Language
English
ISSN
0140-6736
Abstract
Summary Background Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the target systolic blood pressure for optimal outcome is uncertain. We assessed intensive blood pressure lowering compared with guideline-recommended blood pressure lowering in patients treated with alteplase for acute ischaemic stroke. Methods We did an international, partial-factorial, open-label, blinded-endpoint trial of thrombolysis-eligible patients (age [greater than or equal to]18 years) with acute ischaemic stroke and systolic blood pressure 150 mm Hg or more, who were screened at 110 sites in 15 countries. Eligible patients were randomly assigned (1:1, by means of a central, web-based program) within 6 h of stroke onset to receive intensive (target systolic blood pressure 130--140 mm Hg within 1 h) or guideline (target systolic blood pressure Findings Between March 3, 2012, and April 30, 2018, 2227 patients were randomly allocated to treatment groups. After exclusion of 31 patients because of missing consent or mistaken or duplicate randomisation, 2196 alteplase-eligible patients with acute ischaemic stroke were included: 1081 in the intensive group and 1115 in the guideline group, with 1466 (67*4%) administered a standard dose among the 2175 actually given intravenous alteplase. Median time from stroke onset to randomisation was 3*3 h (IQR 2*6--4*1). Mean systolic blood pressure over 24 h was 144*3 mm Hg (SD 10*2) in the intensive group and 149*8 mm Hg (12*0) in the guideline group (p Interpretation Although intensive blood pressure lowering is safe, the observed reduction in intracranial haemorrhage did not lead to improved clinical outcome compared with guideline treatment. These results might not support a major shift towards this treatment being applied in those receiving alteplase for mild-to-moderate acute ischaemic stroke. Further research is required to define the underlying mechanisms of benefit and harm resulting from early intensive blood pressure lowering in this patient group. Funding National Health and Medical Research Council of Australia; UK Stroke Association; Ministry of Health and the National Council for Scientific and Technological Development of Brazil; Ministry for Health, Welfare, and Family Affairs of South Korea; Takeda.