부산대학교 도서관

Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation. Author Affiliation: (1) Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA * Corresponding author Byline: Sanjeethan C. Baksh (1), Elaine Fuchs [fuchs@rockefeller.edu] (1,*)