학술논문
An expanded universe of cancer targets
Document Type
Academic Journal
Author
Hahn, William C.; Bader, Joel S.; Braun, Theodore P.; Califano, Andrea; Clemons, Paul A.; Druker, Brian J.; Ewald, Andrew J.; Fu, Haian; Jagu, Subhashini; Kemp, Christopher J.; Kim, William; Kuo, Calvin J.; McManus, Michael; B. Mills, Gordon; Mo, Xiulei; Sahni, Nidhi; Schreiber, Stuart L.; Talamas, Jessica A.; Tamayo, Pablo; Tyner, Jeffrey W.; Wagner, Bridget K.; Weiss, William A.; Gerhard, Daniela S.; Dancik, Vlado; Gill, Shubhroz; Hua, Bruce; Sharifnia, Tanaz; Viswanathan, Vasanthi; Zou, Yilong; Dela Cruz, Filemon; Kung, Andrew; Stockwell, Brent; Boehm, Jesse; Dempster, Josh; Manguso, Robert; Vazquez, Francisca; Cooper, Lee A.D.; Du, Yuhong; Ivanov, Andrey; Lonial, Sagar; Moreno, Carlos S.; Niu, Qiankun; Owonikoko, Taofeek; Ramalingam, Suresh; Reyna, Matthew; Zhou, Wei; Grandori, Carla; Shmulevich, Ilya; Swisher, Elizabeth; Cai, Jitong; Chan, Issac S.; Dunworth, Matthew; Ge, Yuchen; Georgess, Dan; Grasset, Eloise M.; Henriet, Elodie; Knutsdottir, Hildur; Lerner, Michael G.; Padmanaban, Veena; Perrone, Matthew C.; Suhail, Yasir; Tsehay, Yohannes; Warrier, Manisha; Morrow, Quin; Nechiporuk, Tamilla; Long, Nicola; Saultz, Jennifer; Kaempf, Andy; Minnier, Jessica; Tognon, Cristina E.; Kurtz, Stephen E.; Agarwal, Anupriya; Brown, Jordana; Watanabe-Smith, Kevin; Vu, Tania Q.; Jacob, Thomas; Yan, Yunqi; Robinson, Bridget; Lind, Evan F.; Kosaka, Yoko; Demir, Emek; Estabrook, Joseph; Grzadkowski, Michael; Nikolova, Olga; Chen, Ken; Deneen, Ben; Liang, Han; Bassik, Michael C.; Bhattacharya, Asmita; Brennan, Kevin; Curtis, Christina; Gevaert, Olivier; Ji, Hanlee P.; Karlsson, Kasper A.J.; Karagyozova, Kremena; Lo, Yuan-Hung; Liu, Katherine; Nakano, Michitaka; Sathe, Anuja; Smith, Amber R.; Spees, Kaitlyn; Wong, Wing Hing; Yuki, Kanako; Hangauer, Matt; Kaufman, Dan S.; Balmain, Allan; Bollam, Saumya R.; Chen, Wei-Ching; Fan, QiWen; Kersten, Kelly; Krummel, Matthew; Li, Yun Rose; Menard, Marie; Nasholm, Nicole; Schmidt, Christin; Serwas, Nina K.; Yoda, Hiroyuki
Source
Cell. March 4, 2021, Vol. 184 Issue 5, 1142
Subject
Language
English
ISSN
0092-8674
Abstract
Summary The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.