부산대학교 도서관

Byline: Jessica S. Williams; Thomas A. Kunkel Keywords: ribonucleotide, DNA polymerase, mutagenesis, DNA repair, genome stability Author Notes: This is a work of the US Government and is not subject to copyright protection in the United States Abstract Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease.