학술논문
Impact of cirrhosis in patients undergoing laparoscopic liver resection in a nationwide multicentre survey
Document Type
Academic Journal
Author
Hobeika, C.; Fuks, D.; Cauchy, F.; Goumard, C.; Soubrane, O.; Gayet, B.; Salame, E.; Cherqui, D.; Vibert, E.; Scatton, O.; Nomi, T.; Oudafal, N.; Kawai, T.; Komatsu, S.; Okumura, S.; Petrucciani, N.; Laurent, A.; Bucur, P.; Barbier, L.; Trechot, B.; Nunez, J.; Tedeschi, M.; Allard, M.-A.; Golse, N.; Ciacio, O.; Pittau, G.; Cunha, A. Sa; Adam, R.; Laurent, C.; Chiche, L.; Leourier, P.; Rebibo, L.; Regimbeau, J.-M.; Ferre, L.; Souche, F. R.; Chauvat, J.; Fabre, J.-M.; Jehaes, F.; Mohkam, K.; Lesurtel, M.; Ducerf, C.; Mabrut, J.-Y.; Hor, T.; Paye, F.; Balladur, P.; Suc, B.; Muscari, F.; Millet, G.; El Amrani, M.; Ratajczak, C.; Lecolle, K.; Boleslawski, E.; Truant, S.; Pruvot, F.-R.; Kianmanesh, A.-R.; Codjia, T.; Schwarz, L.; Girard, E.; Abba, J.; Letoublon, C.; Chirica, M.; Carmelo, A.; VanBrugghe, C.; Cherkaoui, Z.; Unterteiner, X.; Memeo, R.; Pessaux, P.; Buc, E.; Lermite, E.; Barbieux, J.; Bougard, M.; Marchese, U.; Ewald, J.; Turini, O.; Thobie, A.; Menahem, B.; Mulliri, A.; Lubrano, J.; Zemour, J.; Fagot, H.; Passot, G.; Gregoire, E.; Hardwigsen, J.; Treut, Y.-P.; Patrice, D.
Source
British Journal of Surgery. Feb 2020, Vol. 107 Issue 3, p268, 10 p.
Subject
Language
English
ISSN
0007-1323
Abstract
Background The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study. Methods This retrospective study included all patients undergoing LLR in 27 centres between 2000 and 2017. Cirrhosis was defined as F4 fibrosis on pathological examination. Short-term outcomes of patients with and without liver cirrhosis were compared after propensity score matching by centre volume, demographic and tumour characteristics, and extent of resection. Results Among 3150 patients included, LLR was performed in 774 patients with (24*6 per cent) and 2376 (75*4 per cent) without cirrhosis. Severe complication and mortality rates in patients with cirrhosis were 10*6 and 2*6 per cent respectively. Posthepatectomy liver failure (PHLF) developed in 3*6 per cent of patients with cirrhosis and was the major cause of death (11 of 20 patients). After matching, patients with cirrhosis tended to have higher rates of severe complications (odds ratio (OR) 1*74, 95 per cent c.i. 0*92 to 3*41; P=0*096) and PHLF (OR 7*13, 0*91 to 323*10; P=0*068) than those without cirrhosis. They also had a higher risk of death (OR 5*13, 1*08 to 48*61; P=0*039). Rates of cardiorespiratory complications (P=0*338), bile leakage (P=0*286) and reoperation (P=0*352) were similar in the two groups. Patients with cirrhosis had a longer hospital stay than those without (11 versus 8days; P=0*018). Centre expertise was an independent protective factor against PHLF in patients with cirrhosis (OR 0*33, 0*14 to 0*76; P=0*010). Conclusion Underlying cirrhosis remains an independent risk factor for impaired outcomes in patients undergoing LLR, even in expert centres. Byline: C. Hobeika,D. Fuks,F. Cauchy,C. Goumard, O. Soubrane, B. Gayet, E. Salame, D. Cherqui, E. Vibert, O. Scatton, , T. Nomi, N. Oudafal, T. Kawai, S. Komatsu, S. Okumura, N. Petrucciani, A. Laurent, P. Bucur, L. Barbier, B. Trechot, J. Nunez, M. Tedeschi, M.-A. Allard, N. Golse, O. Ciacio, G. Pittau, A. Sa Cunha, R. Adam, C. Laurent, L. Chiche, P. Leourier, L. Rebibo, J.-M. Regimbeau, L. Ferre, F. R. Souche, J. Chauvat, J.-M. Fabre, F. Jehaes, K. Mohkam, M. Lesurtel, C. Ducerf, J.-Y. Mabrut, T. Hor, F. Paye, P. Balladur, B. Suc, F. Muscari, G. Millet, M. El Amrani, C. Ratajczak, K. Lecolle, E. Boleslawski, S. Truant, F.-R. Pruvot, A.-R. Kianmanesh, T. Codjia, L. Schwarz, E. Girard, J. Abba, C. Letoublon, M. Chirica, A. Carmelo, C. VanBrugghe, Z. Cherkaoui, X. Unterteiner, R. Memeo, P. Pessaux, E. Buc, E. Lermite, J. Barbieux, M. Bougard, U. Marchese, J. Ewald, O. Turini, A. Thobie, B. Menahem, A. Mulliri, J. Lubrano, J. Zemour, H. Fagot, G. Passot, E. Gregoire, J. Hardwigsen, Y.-P. Treut, D. Patrice