부산대학교 도서관

Insulin-like growth factor 1 (IGF-l) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atheroselerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-l-induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF- 1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging. Key Words; IGF-I--Oxidant stress--Aging--Atherosclerosis--Inflammation. doi: 10.1093/gerona/gls102