부산대학교 도서관

Background Systemic inflammation following curative surgery for colorectal cancer may be associated with increased risk of recurrence. [Correction added on 29 November 2019, after first online publication: text amended for accuracy.] This study investigated whether a clinically suspected infection, for which blood cultures were sent within 30days after surgery for colorectal cancer, was associated with long-term oncological outcomes. Methods This register-based national cohort study included all Danish residents undergoing surgery with curative intent for colorectal cancer between January 2003 and December 2013. Patients who developed recurrence or died within 180days after surgery were not included. Associations between blood cultures taken within 30days after primary surgery and overall survival, disease-free survival and recurrence-free survival were analysed using Cox regression models adjusted for relevant clinical confounders, including demographic data, cancer stage, co-morbidity, blood transfusion, postoperative complications and adjuvant chemotherapy. Results The study included 21349 patients, of whom 3390 (15*9 per cent) had blood cultures taken within 30days after surgery. Median follow-up was 5*6years. Patients who had blood cultures taken had an increased risk of all-cause mortality (hazard ratio (HR) 1*27, 95 per cent c.i. 1*20 to 1*35; P Conclusion A clinically suspected infection requiring blood cultures within 30days of surgery for colorectal cancer was associated with poorer oncological outcomes. Byline: S. K. Watt, T. Fransgaard, T. H. Degett, L. C. Thygesen, T. Benfield, J. D. Knudsen, K. Fuursted, T. G. Jensen, R. B. Dessau, H. C. Schonheyder, J. K. Moller, I. Gogenur