부산대학교 도서관

Byline: Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman, Keywords: anal cancer; anal cytology; high-grade squamous intraepithelial lesion; human papillomavirus; positive predictive value; high-resolution anoscopy BACKGROUND Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. For each participant with a baseline cytological abnormality, the worst histology was recorded at the baseline high-resolution anoscopy and at 6 and 12 months. PPVs for a histological high-grade squamous intraepithelial lesion (HSIL) diagnosis were calculated for each level of baseline cytological abnormality at each time point. RESULTS Among 424 men who completed 3 visits, the PPV of a cytological HSIL increased from 71.6% at the baseline to 86.4% at 6 months and to 92.6% at 12 months (P CONCLUSIONS In a cohort of MSM, a baseline histological HSIL diagnosis after an HSIL cytoprediction is high, and it increases with further examinations over the course of 12 months. Lower levels of cytological abnormalities have significantly lower PPVs. These data can inform patient management and the quality assessment of each aspect of the screening pathway. Cancer Cytopathol 2018;126:136-44. [c] 2017 American Cancer Society. Article Note: We thank Deborah Ekman for her assistance with the photography. The Study of the Prevention of Anal Cancer Study Team includes the following: Brian Acraman, Marjorie K. Adams, Clare Biro, Andrew Carr, Susan Carroll, David Cooper, Alyssa Cornall, Deborah Ekman, Christopher Fairley, Annabelle Farnsworth, Lance Feeney, Suzanne Marie Garland, Russ Gluyas, Andrew Edwin Grulich, Richard John Hillman, Kirsten Howard, Fengyi Jin, Carmella Law, Matthew Law, Kirsten McCaffery, Ross L. McDonald, Patrick McGrath, Susan Pendlebury, Kathy Petoumenos, Samuel Phillips, Isobel Mary Poynten, Garrett Prestage, Adele Richards, Jennifer Margaret Roberts, Daniel Seeds, Sepehr Tabrizi, David James Templeton, Julia Kathleen Thurloe, Winnie Tong, and Rick Varma.