부산대학교 도서관

Summary Mycobacterial infections, both tuberculosis and nontuberculous, are more common in patients with haematological malignancies and haematopoietic stem cell transplant recipients than in the general population--although these infections remain rare. Mycobacterial infections pose both diagnostic and therapeutic challenges. The management of mycobacterial infections is particularly complicated for patients in haematology because of the many drug--drug interactions between antimycobacterial drugs and haematological and immunosuppressive treatments. The management of mycobacterial infections must also consider the effect of delaying haematological management. We surveyed the management practices for latent tuberculosis infection (LTBI) in haematology centres in Europe. We then conducted a meticulous review of the literature on the epidemiology, diagnosis, and management of LTBI, tuberculosis, and nontuberculous mycobacterial infections among patients in haematology, and we formulated clinical guidelines according to standardised European Conference on Infections in Leukaemia (ECIL) methods. In this Review, we summarise the available literature and the recommendations of ECIL 8 for managing mycobacterial infections in patients with haematological malignancies. Author Affiliation: (a) Division of Pulmonology, Geneva University Hospitals, Geneva, Switzerland (b) University of Paris, ECSTRRA Team, Inserm, Paris, France (c) Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy (d) San Martino Polyclinic Hospital, Genoa, Italy (e) Division of Internal Medicine and Infectious Diseases, Saint-Luc University Clinics, Catholic University of Louvain, Brussels, Belgium (f) Division of Pulmonology, Saint Louis Hospital, APHP, University of Paris, Paris, France (g) Department of Radiology, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain (h) Microbiology Department, Raymond Poincaré Hospital, GHU Paris-Saclay, Paris, France (i) Division of Infection and Inflammation, Paris-Saclay University, UVSQ, Inserm, Paris, France (j) Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany (k) German Center for Infection Research (DZIF), TTU Tuberculosis, Borstel, Germany (l) Respiratory Medicine and International Health, University of Lübeck, Lübeck, Germany (m) Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA (n) Department of Pharmaceutical and Pharmacological Sciences, University Hospitals Leuven, University of Leuven, Leuven, Belgium (o) Department of Haematology, University Hospitals Leuven, University of Leuven, Leuven, Belgium (p) Department of Medicine, Section of Infectious Diseases, Hacettepe University Medical School, Ankara, Turkey (q) Department of Haematology, Radboudumc, Nijmegen, Netherlands (r) Department of Haematology, Oncology, and Palliative Care, Ernst von Bergmann Clinic, Potsdam, Germany (s) BMT Unit, Haematology Department, Hospital Clinic, IDIBAPS and Josep Carreras Foundation, Barcelona, Spain (t) Translational Research Unit, Department of Epidemiology and Preclinical Research, Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy (u) Haematology Department, Princess University Hospital, Madrid, Spain * Correspondence to: Prof Anne Bergeron, Division of Pulmonology, Geneva University Hospitals, Geneva 1211, Switzerland Byline: Prof Anne Bergeron, MD [anne.bergeron@hcuge.ch] (a,b), Prof Malgorzata Mikulska, MD (c,d), Julien De Greef, MD (e), Louise Bondeelle, MD (f), Prof Tomas Franquet, MD (g), Prof Jean-Louis Herrmann, PharmD (h,i), Prof Christoph Lange, MD (j,k,l,m), Prof Isabel Spriet, PharmD (n), Prof Murat Akova, MD (p), J Peter Donnelly, PhD (q), Prof Johan Maertens, MD (o), Prof Georg Maschmeyer, MD (r), Prof Montserrat Rovira, MD (s), Prof Delia Goletti, MD (t), Prof Rafael de la Camara, MD (u), Hildegard Greinix, Johan Maertens, Julien De Greef, Monica Slavin, Isabel Spriet, Petr Hubacek, Anne Bergeron, Catherine Cordonnier, Jukka Kanerva, Raoul Herbrecht, Jean-Louis Herrmann, Fanny Lanternier, Louise Bondeelle, Christine Robin, Hermann Einsele, Thomas Lehrnbecher, Andreas Groll, Georg Maschmeyer, Christoph Lange, Marie von Lilienfeld-Toal, Dorothea Pana, Emmanuel Roilides, Csaba Kassa, Diana Averbuch, Dan Engelhard, Simone Cesaro, Malgorzata Mikulska, Livio Pagano, Elio Castagnola, Francesca Compagno, Delia Goletti, Alessio Mesini, Peter J Donnelly, Jan Styczynski, Aida Botelho de Sousa, Mahmoud Aljurf, Rafael de la Camara, David Navarro, Montserrat Rovira, Tomas Franquet, Carol Garcia-Vidal, Per Ljungman, Karlis Paukssen, Roland Ammann, Frédéric Lamoth, Hans Hirsch, Nicole Ritz, Murat Akova, Mansour Ceesay, Adilia Warris, Roy Chemaly