학술논문
Cingulo-opercular control network and disused motor circuits joined in standby mode
Document Type
Report
Author
Newbold, Dillan J.; Gordon, Evan M.; Laumann, Timothy O.; Seider, Nicole A.; Montez, David F.; Gross, Sarah J.; Zheng, Annie; Nielsen, Ashley N.; Hoyt, Catherine R.; Hampton, Jacqueline M.; Ortega, Mario; Adeyemo, Babatunde; Miller, Derek B.; Van, Andrew N.; Marek, Scott; Schlaggar, Bradley L.; Carter, Alexandre R.; Kay, Benjamin P.; Greene, Deanna J.; Raichle, Marcus E.; Petersen, Steven E.; Snyder, Abraham Z.; Dosenbach, Nico U.F.
Source
Proceedings of the National Academy of Sciences of the United States. March 30, 2021, Vol. 118 Issue 13, p1AC, 10 p.
Subject
Language
English
ISSN
0027-8424
Abstract
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoarietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions. disuse | plasticity | fMRI | spontaneous activity | network neuroscience