부산대학교 도서관

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/S1473-3099(18)30349-9 Byline: Naim Ouldali, MD (a,b,c,d), Corinne Levy, MD [corinne.levy@activ-france.fr] (b,e,f,g,*), Emmanuelle Varon, MD (h), Prof Stephane Bonacorsi, MD (i,j), Stephane Bechet, MSc (a,b), Prof Robert Cohen, MD (a,b,e,f,g,k), Francois Angoulvant, MD (b,c,d), Marie Noelle Adam, Ilhem Agha-Mir, Sylvia Akitani, Marlene Amara, Guillaume Arlet, Valerie Asensio, Fanny Autret, Julien Baleine, Guilaine Barnaud, Alain Barrans, Katia Barsotti, Romain Basmaci, Nathalie Bednarek, Abdelmalek Belgaid, Gregoire Benoist, Anne Bertrou, Helene Biessy, Valerie Biran, Veronique Blanc, Elodie Blondel, Pascal Bolot, Claude Bosi, Sophie Boyer, Jacques Brouard, Bernadette Cartier-Riviere, Francoise Cascarigny, Christian Cattoen, Anne Chace, Martin Chalumeau, Jean Marc Chamouilli, Chantal Chaplain, Sylvie Charachon, Anne Charbonneau, Mireille Cheron, Bertrand Chevallier, Francis Chomienne, Gery Courouble, Nevena Danekova, Anne Dao-Dubremetz, Patrick Daoud, Stephane Dauger, Christophe De Champs, Daniele De Luca, Andre De Briel, Marion Decobert, Delphine Desbois, Veronique Despert, Rodrigue Dessein, Emmanuelle Dessioux, Katherine Dieckmann, Marie Aliette Dommergues, Elodie Dorangeon, Florence Doucet-Populaire, Francois Dubos, Gregory Dubourg, Marie Josee Dufour, Veronique Duval, Laurence Eitenschenck, Ralph Epaud, Francoise Evreux, Didier Eyer, Stephanie Eyssette-Gayraud, Chrystele Fabbro, Albert Faye, Agnes Ferroni, Marie Pierre Fos, Serge Gallet, Caroline Garandeau, Helene Garrec, Jean Gaschignard, Joel Gaudelus, Laurent Geniez, Florent Girard, Catherine Glastre, Isabelle Glatz, Alain Goudeau, Anne Gougeon Jollivet, Pierre Goumy, Francois Gouraud, Alain Goux, Anna Grando, Emmanuel Grimprel, Olivier Guilluy, Gael Guyon, Caroline Guyot, Herve Haas, Isabelle Haegy-Doehring, Muriel Halna, Farida Hamdad, Severine Haouisee, Christian Herve, Rachel Heyman Guenais, Anne Cecile Hochart, Stephanie Honore Bouakline, Nathalie Hubert, Didier Jan, Etienne Javouhey, Emmanuel Jeannot, Josette Jehan, Marie Emmanuelle Juvin, Nicolas Kalach, Ali Khalfi, Philippe Labrune, Leila Lafendi, Hakim Lahrach, Norbert Laisney, Danielle Landragin, Fabrice Lapeyre, Vincent Laugel, Elise Launay, Jean Philippe Lavigne, Marc Le Bideau, Sylvie Ledru, Philippe Lehours, Nejib Lejri, Olivier Lemenand, Mathie Lorrot, Pierre Lureau, Celestin M'Bamba, Valerie Macchi, Fouad Madhi, Valerie Marcou, Mariane Marin, Sandrine Anne Martha, Alain Martinot, Ellia Mezgueldi, Maite Micaelo, Karen Milcent, Delphine Minette Brunel, Didier Moissenet, Olivier Moquet, Cyril Morisot, Eric Moulene, Nawal Nicola, Abdelaziz Oulepsir, Leatitia Pantalone, Pierre Patoz, Beatrice Pellegrino, Delphine Penel-Capelle, Marie Helene Pierre, Didier Pinquier, Aurelia Pitsch, Claire Plassart, Huong Porcheret, Marie Francoise Prere, Josette Raymond, Agnes Rey, Florence Richardin, Patricia Roussellier, Anne Laure Roux, Danielle Roybet, Ahmed Sadik, Jean Sarlangue, Simone Saumureau, Isabelle Savoy, Jean Marc Schneider, Olivier Sebag, Valerie Sivadon-Tardy, Nicolas Soustelle, Anthony Texier, Maxime Thouvenin, Julie Toubiana, Frederic Tronc, Eterne Twizeyimana, Anne Vachee, Veronqiue Vernet-Garnier, Christine Vervel, Jeremie Violette, Frederic Wallet, Laure Warin, Mohamed Amine Yangui, Hubert Ythier, Brigitte Zimmermann Summary Background Successive implementation of seven-valent then 13-valent pneumococcal conjugate vaccines (PCVs) led to a marked decrease in pneumococcal disease burden, including pneumococcal meningitis. We assessed the long-term effect of implementation of PCVs on incidence of pneumococcal meningitis in children in France over a 16-year period. Methods We did a quasi-experimental, population-based interrupted time-series analysis with a nationwide prospective survey over 16 years in France, recruiting children aged younger than 15 years from 227 paediatric wards from January, 2001, to December, 2016. The main outcome by the time-series model was the estimated incidence of pneumococcal meningitis per 100,000 children (of a population of 12*6 million children in 2017) before and after PCV7 and PCV13 implementation. The time-series model was based on segmented regression with autoregressive error. Findings We enrolled 1778 children with pneumococcal meningitis. PCV13 implementation led to a significant reduction in monthly incidence of pneumococcal meningitis from 0*12 per 100,000 children before PCV13 to a nadir of 0*07 in December, 2014 (-38%, 95% CI -56*1 to -20*4; p Interpretation The early effect of PCV13 implementation greatly reduced the incidence of pneumococcal meningitis in children less than 15 years old. However, a sharp rebound in incidence linked to the emergence of serotype 24F compromised the long-term PCV efficacy. If confirmed in future studies and in other countries, pneumococcal meningitis incidence rebound and 24F emergence should be considered when developing next-generation PCVs. Funding The French Pediatric Infectious Diseases Group, Association Clinique et Therapeutique Infantile du Val de Marne, Pfizer, and for the National Reference Centre for Pneumococci, the French National Health Agency. Author Affiliation: (a) Association Clinique et Therapeutique Infantile du Val-de-Marne, Saint Maur-des-Fosses, France (b) Groupe de Pathologie Infectieuse Pediatrique, Paris, France (c) Unite d'epidemiologie clinique, Assistance Publique-Hopitaux de Paris, Hopital Robert Debre, ECEVE UMR 1123, Paris, France (d) Urgences pediatriques, Hopital Necker Enfants Malades, Universite Paris Descartes, Paris, France (e) Association Francaise de Pediatrie Ambulatoire, Saint-Germain-en-Laye, Paris, France (f) Universite Paris Est, IMRB-GRC GEMINI, Creteil, France (g) Clinical Research Center, Centre Hospitalier Intercommunal de Creteil, Creteil, France (h) National Reference Center for Pneumococci, Laboratoire de Microbiologie, Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Paris, France (i) Universite Paris Diderot, Sorbonne Paris Cite, France (j) Service de Microbiologie, Assistance Publique-Hopitaux de Paris, Hopital Robert-Debre, Paris, France (k) Unite Court Sejour, Petits Nourrissons, Service de Neonatalogie, Centre Hospitalier Intercommunal de Creteil, France * Correspondence to: Dr Corinne Levy, Association Clinique et Therapeutique Infantile du Val-de-Marne, 94100 Saint-Maur-des-Fosses, France (footnote)[Dagger] Group members listed at the end of the paper