학술논문
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
Document Type
Report
Author
Glynn, Nancy W.; Gmelin, Theresa; Santanasto, Adam J.; Lovato, Laura C.; Lange-Maia, Brittney S.; Nicklas, Barbara J.; Fielding, Roger A.; Manini, Todd M.; Myers, Valerie H.; Rekeneire, Nathalie; Spring, Bonnie J.; Pahor, Marco; King, Abby C.; Rejeski, W. Jack; Newman, Anne B.; Guralnik, Jack M.; Anton, Stephen D.; Buford, Thomas W.; Leeuwenburgh, Christiaan; Nayfield, Susan G.; Caudle, Connie; Crump, Lauren; Holmes, Latonia; Lee, Jocelyn; Lu, Ching-ju; Miller, Michael E.; Espeland, Mark A.; Ambrosius, Walter T.; Applegate, William; Beavers, Daniel P.; Byington, Robert P.; Cook, Delilah; Furberg, Curt D.; Harvin, Lea N.; Henkin, Leora; Hepler, John; Hsu, Fang-Chi; Joyce, Kathy; Lovato, Laura; Pierce, Juan; Roberson, Wesley; Robertson, Julia; Rushing, Julia; Rushing, Scott; Stowe, Cynthia L.; Walkup, Michael P.; Hire, Don; Katula, Jeffrey A.; Brubaker, Peter H.; Mihalko, Shannon L.; Jennings, Janine M.; Chen, Shyh-Huei; Pierce, June J.; Chen, Haiying; Hadley, Evan C.; Romashkan, Sergei; Patel, Kushang V.; Bethesda, Kushang V.; Bonds, Denise; McDermott, Mary M.; Spring, Bonnie; Hauser, Joshua; Kerwin, Diana; Domanchuk, Kathryn; Graff, Rex; Rego, Alvito; Church, Timothy S.; Blair, Steven N.; Monce, Ron; Britt, Nathan E.; Harris, Melissa Nauta; McGucken, Ami Parks; Rodarte, Ruben; Millet, Heidi K.; Tudor-Locke, Catrine; Butitta, Ben P.; Donatto, Sheletta G.; Cocreham, Shannon H.; Castro, Cynthia M.; Haskell, William L.; Stafford, Randall S.; Pruitt, Leslie A.; Yank, Veronica; Berra, Kathy; Bell, Carol; Thiessen, Rosita M.; Youngman, Kate P.; Virgen, Selene B.; Maldonado, Eric; Tarin, Kristina N.; Klaftenegger, Heather; Prosak, Carolyn A.; Campero, Ines; Garcia, Dulce M.; Soto, Jose; Chio, Linda; Hoskins, David; Nelson, Miriam E.; Folta, Sara C.; Phillips, Edward M.; Liu, Christine K.; McDavitt, Erica C.; Reid, Kieran F.; Kirn, Dylan R.; Pasha, Evan P.; Kim, Won S.; Krol, Julie M.; Beard, Vince E.; Tsiroyannis, Eleni X.; Hau, Cynthia; Marsiske, Michael; Sandesara, Bhanuprasad D.; Black, Mieniecia L.; Burk, William L.; Hoover, Brian M.; Knaggs, Jeffrey D.; Marena, William C.; Korytov, Irina; Curtis, Stephanie D.; Lorow, Megan S.; Goswami, Chaitalee S.; Lewis, Melissa A.; Kamen, Michelle; Bitz, Jill N.; Stanton, Brian K.; Hicks, Tamika T.; Gay, Charles W.; Xie, Chonglun; Morris, Holly L.; Singletary, Floris F.; Causer, Jackie; Yonce, Susan; Radcliff, Katie A.; Smith, Mallorey Picone; Scott, Jennifer S.; Rodriguez, Melissa M.; Fitch, Margo S.; Dunn, Mendy C.; Schllesinger, Jessica Q.; Studenski, Stephanie A.; Goodpaster, Bret H.; Lopez, Oscar; Nadkarni, Neelesh K.; Ives, Diane G.; Newman, Mark A.; Grove, George; Williams, Kathy; Bonk, Janet T.; Rush, Jennifer; Kost, Piera; Vincent, Pamela; Gerger, Allison; Romeo, Jamie R.; Monheim, Lauren C.; Kritchevsky, Stephen B.; Marsh, Anthony P.; Brinkley, Tina E.; Demons, Jamehl S.; Sink, Kaycee M.; Kennedy, Kimberly; Shertzer-Skinner, Rachel; Wrights, Abbie; Fries, Rose; Barr, Deborah; Gill, Thomas M.; Axtell, Robert S.; Kashaf, Susan S.; McGloin, Joanne M.; Mautner, Raeleen; Huie-White, Sharon M.; Bianco, Luann; Zocher, Janice; Wu, Karen C.; Shepard, Denise M.; Fennelly, Barbara; Castro, Rina; Halpin, Sean; Brennan, Matthew; Barnett, Theresa; Iannone, Lynne P.; Zenoni, Maria A.; Bugaj, Julie A.; Bailey, Christine; Charpentier, Peter; Hawthorne-Jones, Geraldine; Mignosa, Bridget; Lewis, Lynn; Williamson, Jeff; Sink, Kaycee M; Hendrie, Hugh C.; Rapp, Stephen R.; Verghese, Joe; Woolard, Nancy; Espeland, Mark; Jennings, Janine; Wilson, Valerie K.; Pepine, Carl J.; Ariet, Mario; Handberg, Eileen; Deluca, Daniel; Hill, James; Szady, Anita; Chupp, Geoffrey L.; Flynn, Gail M.; Hankinson, John L.; Vaz Fragoso, Carlos A.; Groessl, Erik J.; Kaplan, Robert M.
Source
Journal of the American Geriatrics Society. March 2020, Vol. 68 Issue 3, p619, 6 p.
Subject
Language
English
ISSN
0002-8614
Abstract
Keywords: fatigability; older adults; health education; exercise OBJECTIVES Our aim was to examine the impacts of baseline fatigue on the effectiveness of a physical activity (PA) intervention to prevent major mobility disability (MMD) and persistent major mobility disability (PMMD) in participants from the Lifestyle Interventions and Independence for Elders (LIFE) study. DESIGN Prospective cohort of individuals aged 65years or older undergoing structured PA intervention or health education (HE) for a mean of 2.6years. SETTING LIFE was a multicenter eight-site randomized trial that compared the efficacy of a structured PA intervention with an HE program in reducing the incidence of MMD. PARTICIPANTS Study participants (N=1591) at baseline were 78.9[+ or -]5.2years of age, with low PA and at risk for mobility impairment. MEASUREMENTS Self-reported fatigue was assessed using the modified trait version of the Exercise-Induced Feelings Inventory, a six-question scale rating energy levels in the past week. Responses ranged from 0 (none of the time) to 5 (all of the time). Total score was calculated by averaging across questions; baseline fatigue was based on the median split: 2 or higher=more fatigue (N=856) and lower than 2=less fatigue (N=735). Participants performed a usual-paced 400-m walk every 6months. We defined incident MMD as the inability to walk 400-m at follow-up visits; PMMD was defined as two consecutive walk failures. Cox proportional hazard models quantified the risk of MMD and PMMD in PA vs HE stratified by baseline fatigue adjusted for covariates. RESULTS Among those with higher baseline fatigue, PA participants had a 29% and 40% lower risk of MMD and PMMD, respectively, over the trial compared with HE (hazard ratio [HR] for MMD=.71; 95% confidence interval [CI] =.57-.90; P=.004) and PMMD (HR=.60; 95% CI=.44-.82; P=.001). For those with lower baseline fatigue, no group differences in MMD (P=.36) or PMMD (P=.82) were found. Results of baseline fatigue by intervention interaction was MMD (P=.18) and PMMD (P=.05). CONCLUSION A long-term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue. J Am Geriatr Soc 68:619-624, 2020 Article Note: The LIFE Study Group is listed in Appendix S1. Preliminary findings were presented at the American College of Sports Medicine Annual Meeting, San Diego, California, May 2015. CAPTION(S): Supplementary Appendix S1: The Lifestyle Interventions and Independence for Elders Study Group. Byline: Nancy W. Glynn, Theresa Gmelin, Adam J. Santanasto, Laura C. Lovato, Brittney S. Lange-Maia, Barbara J. Nicklas, Roger A. Fielding, Todd M. Manini, Valerie H. Myers, Nathalie Rekeneire, Bonnie J. Spring, Marco Pahor, Abby C. King, W. Jack Rejeski, Anne B. Newman, Marco Pahor, Jack M. Guralnik, Stephen D. Anton, Thomas W. Buford, Christiaan Leeuwenburgh, Susan G. Nayfield, Todd M. Manini, Connie Caudle, Lauren Crump, Latonia Holmes, Jocelyn Lee, Ching-ju Lu, Michael E. Miller, Mark A. Espeland, Walter T. Ambrosius, William Applegate, Daniel P. Beavers, Robert P. Byington, Delilah Cook, Curt D. Furberg, Lea N. Harvin, Leora Henkin, John Hepler, Fang-Chi Hsu, Kathy Joyce, Laura Lovato, Juan Pierce, Wesley Roberson, Julia Robertson, Julia Rushing, Scott Rushing, Cynthia L. Stowe, Michael P. Walkup, Don Hire, W. Jack Rejeski, Jeffrey A. Katula, Peter H. Brubaker, Shannon L. Mihalko, Janine M. Jennings, Shyh-Huei Chen, June J. Pierce, Haiying Chen, Evan C. Hadley, Sergei Romashkan, Kushang V. Patel, Bethesda, Denise Bonds, Mary M. McDermott, Bonnie Spring, Joshua Hauser, Diana Kerwin, Kathryn Domanchuk, Rex Graff, Alvito Rego, Timothy S. Church, Steven N. Blair, Valerie H. Myers, Ron Monce, Nathan E. Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Rodarte, Heidi K. Millet, Catrine Tudor-Locke, Ben P. Butitta, Sheletta G. Donatto, Shannon H. Cocreham, Abby C. King, Cynthia M. Castro, William L. Haskell, Randall S. Stafford, Leslie A. Pruitt, Veronica Yank, Kathy Berra, Carol Bell, Rosita M. Thiessen, Kate P. Youngman, Selene B. Virgen, Eric Maldonado, Kristina N. Tarin, Heather Klaftenegger, Carolyn A. Prosak, Ines Campero, Dulce M. Garcia, Jose Soto, Linda Chio, David Hoskins, Roger A. Fielding, Miriam E. Nelson, Sara C. Folta, Edward M. Phillips, Christine K. Liu, Erica C. McDavitt, Kieran F. Reid, Dylan R. Kirn, Evan P. Pasha, Won S. Kim, Julie M. Krol, Vince E. Beard, Eleni X. Tsiroyannis, Cynthia Hau, Todd M. Manini, Marco Pahor, Stephen D. Anton, Thomas W. Buford, Michael Marsiske, Susan G. Nayfield, Bhanuprasad D. Sandesara, Mieniecia L. Black, William L. Burk, Brian M. Hoover, Jeffrey D. Knaggs, William C. Marena, Irina Korytov, Stephanie D. Curtis, Megan S. Lorow, Chaitalee S. Goswami, Melissa A. Lewis, Michelle Kamen, Jill N. Bitz, Brian K. Stanton, Tamika T. Hicks, Charles W. Gay, Chonglun Xie, Holly L. Morris, Floris F. Singletary, Jackie Causer, Susan Yonce, Katie A. Radcliff, Mallorey Picone Smith, Jennifer S. Scott, Melissa M. Rodriguez, Margo S. Fitch, Mendy C. Dunn, Jessica Q. Schllesinger, Anne B. Newman, Stephanie A. Studenski, Bret H. Goodpaster, Oscar Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Diane G. Ives, Mark A. Newman, George Grove, Kathy Williams, Janet T. Bonk, Jennifer Rush, Piera Kost, Pamela Vincent, Allison Gerger, Jamie R. Romeo, Lauren C. Monheim, Stephen B. Kritchevsky, Anthony P. Marsh, Tina E. Brinkley, Jamehl S. Demons, Kaycee M. Sink, Kimberly Kennedy, Rachel Shertzer-Skinner, Abbie Wrights, Rose Fries, Deborah Barr, Thomas M. Gill, Robert S. Axtell, Susan S. Kashaf, Nathalie Rekeneire, Joanne M. McGloin, Raeleen Mautner, Sharon M. Huie-White, Luann Bianco, Janice Zocher, Karen C. Wu, Denise M. Shepard, Barbara Fennelly, Rina Castro, Sean Halpin, Matthew Brennan, Theresa Barnett, Lynne P. Iannone, Maria A. Zenoni, Julie A. Bugaj, Christine Bailey, Peter Charpentier, Geraldine Hawthorne-Jones, Bridget Mignosa, Lynn Lewis, Jeff Williamson, Kaycee M Sink, Hugh C. Hendrie, Stephen R. Rapp, Joe Verghese, Nancy Woolard, Mark Espeland, Janine Jennings, Valerie K. Wilson, Carl J. Pepine, Mario Ariet, Eileen Handberg, Daniel Deluca, James Hill, Anita Szady, Geoffrey L. Chupp, Gail M. Flynn, Thomas M. Gill, John L. Hankinson, Carlos A. Vaz Fragoso, Erik J. Groessl, Robert M. Kaplan