학술논문
Detection of tumor invasive biomarker using a peptamer of signal conversion and signal amplification
Document Type
Report
Author
Source
Analytical Chemistry. April 5, 2016, Vol. 88 Issue 7, p3662, 7 p.
Subject
Language
English
ISSN
0003-2700
Abstract
The article describes the designing of a switchable peptide, inspired by the structural and functional features of proteins in cell signaling. This switchable peptide, termed opeptamer,o can react to ligand binding with conformational change and activation/deactivation of catalytic ability. Moreover, the peptamer is constructed by elaborate integration of several different peptide motifs with targeting and catalytic abilities; the distinct switching on/off of catalytic activity allows a bioassay of tissue integrin expression in clinical samples of thyroid carcinoma.