학술논문
Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18
Document Type
Report
Author
Source
Biochemistry. April 12, 2011, Vol. 50 Issue 14, 2756-2768
Subject
Language
English
ISSN
0006-2960
Abstract
The interaction between cross-reactive HIV-1 neutralizing human monoclonal antibody m18 and [HIV-1.sub.YU-2] gp120 is explored to understand the role of this antibody which inhibits the entry of virus into cells. The results obtained argue that m18, rather than mimicking CD4 directly, suppresses both receptor binding site functions of HIV-1 gp120 by stabilizing a nonproductive conformation of the envelope protein.