학술논문
Anion binding to hydrophobic concavity is central to the salting-in effects of Hofmeister chaotropes
Document Type
Report
Author
Source
Journal of the American Chemical Society. May 18, 2011, Vol. 133 Issue 19, p7344
Subject
Language
English
ISSN
0002-7863
Abstract
The first direct evidence for affinity of chaotropic anions for hydrophobic concavity and competition between a convex hydrophobe and the anion for a binding site that leads to the apparent weakening of the hydrophobic effect by chaotropes is presented. The results revealed that chaotropes primarily induced protein solubilization by direct binding to concavity in the molten globule state of a protein.