부산대학교 도서관

Keywords Race; Ethnicity; Thyroid nodules; Thyroid cancer; Risk stratification; Lymph node metastasis Highlights * Blacks had a lower risk of thyroid malignancy compared to other racial groups. * Blacks with thyroid cancer were less likely to present with extensive disease. * Socioeconomic factors did not alter the racial disparity of thyroid cancer. Abstract Background Few studies have compared the features of thyroid cancer among races and ethnicities. We hypothesized that race and ethnicity may influence the frequency and features of thyroid malignancy in thyroid nodules. Method This was a retrospective chart review of patients between 2013 and 2020 who underwent thyroidectomy. Results In the analysis of 2737 patients, thyroid cancer was less prevalent among Blacks (24.0% vs Whites 52.1%, Hispanics 58.7%, Asians 71.7%, and Others 57.9%, p < 0.001). Thyroid cancer in Blacks was less likely to have extrathyroidal extension (9.7% vs Whites 18.6%, Hispanics 25.8%, Asians 18.2%, and Others 17.8%, p = 0.01), overall nodal involvement (12.4% vs Whites 31.1%, Hispanics 37.5%, Asians 36.3%, and Others 30.1%, p < 0.01), and lateral neck metastasis (4.4% vs Whites 10.8%, Hispanics 6.3%, Asians 13.2%, and Others 9.6%, p = 0.02). Conclusions Race and ethnicity may play important roles in the risk of malignancy as well as in the extent of thyroid cancer. Author Affiliation: (a) MedStar-Washington Hospital Center, Division of Endocrine Surgery, 110 Irving St NW, Washington, DC, 20010, USA (b) MedStar-Georgetown University Hospital, Department of Surgery, 3800 Reservoir Rd NW, Washington, DC, 20007, USA (c) Georgetown University School of Medicine, 3900 Reservoir Rd NW, Washington, DC, 20007, USA (d) MedStar-Washington Hospital Center, Section of Endocrinology, 110 Irving St NW, Washington DC, 20010, USA (e) MedStar Health Research Institute, Thyroid Cancer Unit, 100 Irving St NW, Washington, DC, 20010, USA * Corresponding author. MedStar-Washington Hospital Center, Division of Endocrine Surgery, 110 Irving St NW, POB 2200 North, Washington, DC, 20010, USA. Article History: Received 30 May 2021; Revised 23 August 2021; Accepted 22 September 2021 Byline: Hui Zheng [Hui.zheng@medstar.net] (a,b,*), Victoria Lai (a), Jana Lu (c), Jin K. Kang (a,b), Erin A. Felger (a), Nancy M. Carroll (a), Kenneth D. Burman (d), Leonard Wartofsky (e), Jennifer E. Rosen (a)