부산대학교 도서관

Keywords: antibody titers; BNT162b2 vaccine; COVID-19; disability; frailty; immunogenicity; nursing homes; older adults Abstract Background There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2 in older adults in long-term care facilities (LTCFs) with frailty, disability, or cognitive impairment. We aimed to determine IgG antibody titer loss in older adults in LTCFs. Methods This is a multicenter longitudinal cohort study including 127 residents (90 females and 37 males) with a mean age of 82.7years (range 65-99) with different frailty and disability profiles in two LTCFs in Albacete, Spain. Residents received two doses of BNT162b2 as per label, and antibody levels were determined 1 and 6 months after the second dose. Age, sex, previous history of coronavirus disease 2019 (COVID-19), comorbidity (Charlson Index), performance in activities of daily living (Barthel Index), frailty (FRAIL instrument), and cognitive status were assessed. Results The mean antibody titers 1 and 6 months after the second vaccine dose were 32,145AU/ml (SD 41,206) and 6182AU/ml (SD 13,316), respectively. Across all participants, the median antibody titer loss measured 77.6% (interquartile range [IQR] 23.8%). Notably, the decline of titers in individuals with pre-vaccination COVID-19 infection was significantly lower than in those without a history of SARS-CoV-2 infection (72.2% vs. 85.3%; p Conclusions Older adults in LTCFs experience a rapid loss of antibodies over the first 6months after the second dose of BNT162b2 vaccine. Only pre-vaccination COVID-19 is associated with a slower rate of antibody decrease. Our data support immunization with a third dose in this vulnerable, high-risk population. Article Note: Funding informationThis project received specific funding by the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain, Ayuda cofinanciada por el Fondo Europeo de Desarrollo Regional FEDER Una Manera de hacer Europa (grant number COV20/00004). In addition, this work was supported by CIBERFES, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, España, Ayuda cofinanciada por el Fondo Europeo de Desarrollo Regional FEDER Una Manera de hacer Europa (grant number CB16/10/00408). Byline: Sergio Salmerón Ríos, Elisa Belén Cortés Zamora, Almudena Avendaño Céspedes, Luis Romero Rizos, Pedro Manuel Sánchez-Jurado, Ginés Sánchez-Nievas, Marta Mas Romero, María Teresa Tabernero Sahuquillo, José Joaquín Blas Señalada, Antonio Murillo Romero, Inmaculada García Nogueras, Juan de Dios Estrella Cazalla, Fernando Andrés-Pretel, Volker Martin Lauschke, Justin Stebbing, Pedro Abizanda