학술논문
Fc[gamma]RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
Document Type
Author abstract
Report
Report
Author
Source
Proceedings of the National Academy of Sciences of the United States. Nov 9, 2010, Vol. 107 Issue 45, p19396, 6 p.
Subject
Language
English
ISSN
0027-8424
Abstract
Cellular Fc[gamma] receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fc[gamma] receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in Fc[gamma]RIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating Fc[gamma]Rs. To study the role of individual activating FC[gamma]RS for IgG subclass activity, we generated an Fc[gamma]RIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity. autoimmune disease | immunoglobulin G | inflammation doi/ 10.1073/pnas.1014515107