부산대학교 도서관

Background: Hydrofluoric acid (HF) ingestion can be rapidly fatal. Toxicity results when absorbed fluoride ions bind with divalent cations resulting in systemic hypocalcemia and hypomagnesemia. Administration of calcium or magnesium salts has been recommended because they combine with fluoride to form insoluble salts. This approach has never been studied in a whole animal model. We hypothesized that co-administration of calcium or magnesium salts would prolong survival in fluoride poisoned mice. Methods: We conducted a randomized, placebo-controlled trial using two oral decontamination methods in a mouse model of HF toxicity. Preliminary studies showed that mice given 3 mmol/kg of aqueous HF orally died within 60 minutes. Using this model, 1.5 mmol/kg of either Ca[Cl.sub.2] or Mg[SO.sub.4] was pre-mixed with the HF solution and given by gavage. Control animals received 3 mmol/kg of HF and saline by gavage. Animals were assigned to treatment groups by forced randomization and time to death was recorded in minutes by unblinded observers. Results: Mean survival in minutes (95% CI) for the groups: Control 34 (15-54); Ca[Cl.sub.2] 40 (24-57); Mg[SO.sub.4] 36 (24-48). P-value was 0.8149 by one-way ANOVA, (not statistically significant). Conclusion: Co-administration of calcium chloride or magnesium sulfate in HF-poisoned mice did not prolong survival. These data do not support administration of these agents following ingestion of HF.
Delgado JH, Heard K. Rocky Mountain Poison & Drug Center--Denver Health; University of Colorado Health Sciences Center, Denver, [...]