학술논문
The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling
Document Type
Academic Journal
Author
Source
The Journal of Cell Biology. March 23, 1998, Vol. 140 Issue 6, p1485, 11 p.
Subject
Language
ISSN
0021-9525
Abstract
Caspase-3-mediated proteolysis is crucial to the apoptotic process, and studies have shown a central role for mitochondrial proteins in caspase-3 activation. It is demonstrated that the caspase-3 proenzyme has mitochondrial and cytosolic distribution in nonapoptotic cells. It is proposed that the caspase-3 precursor molecule mitochondrial subpopulation is linked to a distinct subset of Bcl-2 sensitive apoptotic signaling pathways.