학술논문
Protein kinase C(epsilon) is localized to the Golgi via its zinc-finger domain and modulates Golgi function
Document Type
Academic Journal
Source
Proceedings of the National Academy of Sciences of the United States. Feb 28, 1995, Vol. 92 Issue 5, p1406, 5 p. photograph
Subject
Language
ISSN
0027-8424
Abstract
Analysis of NIH 3T3 cell lines overexpressing holo-protein kinase C(epsilon) (PKC(epsilon)) and its derivatives indicates exclusive localization of the zinc-finger domain at the Golgi network, implying the role of PKC(epsilon) in processes involving Golgi and the ability of the zinc-finger domain to function as a subcellular localization signal. The cells expressing the zinc-finger domains cannot secrete sulfated glycosaminoglycans.