학술논문
Effect of Chitosan on the Number of Streptococcus mutans in Saliva: A Meta-Analysis and Systematic Review
Document Type
Academic Journal
Author
Source
International Journal of Molecular Sciences. October 2023, Vol. 24 Issue 20
Subject
Language
English
ISSN
1422-0067
Abstract
Author(s): Virág Róna [1,2]; Bulcsú Bencze [1,2]; Kata Kelemen [1,2]; Dániel Végh [1,2]; Réka Tóth [2]; Tamás Kói [2,3]; Péter Hegyi [2,4,5]; Gábor Varga [2,6]; Noémi Katinka Rózsa [2,7]; Zoltán [...]
We conducted a meta-analysis and systematic review to investigate the efficacy of chitosan-containing chewing gums, and to test their inhibitory effects on Streptococcus mutans. The systematic search was performed in three databases (Cochrane Library, EMBASE, and PubMed) and included English-language randomized–controlled trials to compare the efficacy of chitosan in reducing the number of S. mutans. To assess the certainty of evidence, the GRADE tool was used. Mean differences were calculated with a 95% confidence interval for one outcome: bacterial counts in CFU/mL. The protocol of the study was registered on PROSPERO, registration number CRD42022365006. Articles were downloaded (n = 6758) from EMBASE (n = 2255), PubMed (n = 1516), and Cochrane (n = 2987). After the selection process, a total of four articles were included in the qualitative synthesis and three in the quantitative synthesis. Our results show that chitosan reduced the number of bacteria. The difference in mean quantity was −4.68 × 10[sup.5]. The interval of the random-effects model was [−2.15 × 10[sup.6]; 1.21 × 10[sup.6]] and the prediction interval was [1.03 × 10[sup.7]; 9.40 × 10[sup.6]]. The I2 value was 98% (p = 0.35), which indicates a high degree of heterogeneity. Chitosan has some antibacterial effects when used as a component of chewing gum, but further studies are needed. It can be a promising antimicrobial agent for prevention.
We conducted a meta-analysis and systematic review to investigate the efficacy of chitosan-containing chewing gums, and to test their inhibitory effects on Streptococcus mutans. The systematic search was performed in three databases (Cochrane Library, EMBASE, and PubMed) and included English-language randomized–controlled trials to compare the efficacy of chitosan in reducing the number of S. mutans. To assess the certainty of evidence, the GRADE tool was used. Mean differences were calculated with a 95% confidence interval for one outcome: bacterial counts in CFU/mL. The protocol of the study was registered on PROSPERO, registration number CRD42022365006. Articles were downloaded (n = 6758) from EMBASE (n = 2255), PubMed (n = 1516), and Cochrane (n = 2987). After the selection process, a total of four articles were included in the qualitative synthesis and three in the quantitative synthesis. Our results show that chitosan reduced the number of bacteria. The difference in mean quantity was −4.68 × 10[sup.5]. The interval of the random-effects model was [−2.15 × 10[sup.6]; 1.21 × 10[sup.6]] and the prediction interval was [1.03 × 10[sup.7]; 9.40 × 10[sup.6]]. The I2 value was 98% (p = 0.35), which indicates a high degree of heterogeneity. Chitosan has some antibacterial effects when used as a component of chewing gum, but further studies are needed. It can be a promising antimicrobial agent for prevention.