학술논문
Association between SARS-CoV-2 infection and select symptoms and conditions 31 to 150 days after testing among children and adults
Document Type
Academic Journal
Author
Zhang, Yongkang; Romieu-Hernandez, Alfonso; Boehmer, Tegan K.; Azziz-Baumgartner, Eduardo; Carton, Thomas W.; Gundlapalli, Adi V.; Fearrington, Julia; Nagavedu, Kshema; Dea, Katherine; Moyneur, Erick; Cowell, Lindsay G.; Kaushal, Rainu; Mayer, Kenneth H.; Puro, Jon; Rasmussen, Sonja A.; Thacker, Deepika; Weiner, Mark G.; Saydah, Sharon; Block, Jason P.; Ahmad, Faraz S.; Bunnell, H. Timothy; Carrasquillo, Olveen; Chrischilles, Elizabeth A.; Christakis, Dimitri A.; Chang, Bernard P.; Curtis, Janis L.; Fernandez, Soledad A.; Forrest, Christopher B.; Fort, Daniel; Hanauer, David A.; Hess, Rachel; Horne, Benjamin D.; Giordano, Philip; Hogan, William; Mosa, Abu Saleh Mohammad; McClay, James C.; Nandhakumar, Samyuktha; Nolan, Bridget; Obeid, Jihad S.; Ostasiewski, Brian; Paranjape, Anuradha; Patel, Lav; Rao, Suchitra; Robinson, Patricia S.; Trick, William E.; Silverstein, Jonathan C.
Source
BMC Infectious Diseases. February 10, 2024, Vol. 24 Issue 1
Subject
Language
English
ISSN
1471-2334
Abstract
Author(s): Yongkang Zhang[sup.1], Alfonso Romieu-Hernandez[sup.2], Tegan K. Boehmer[sup.3], Eduardo Azziz-Baumgartner[sup.3], Thomas W. Carton[sup.4], Adi V. Gundlapalli[sup.3], Julia Fearrington[sup.5], Kshema Nagavedu[sup.5], Katherine Dea[sup.6], Erick Moyneur[sup.6], Lindsay G. Cowell[sup.7], Rainu Kaushal[sup.1], Kenneth [...]
Background An increasing number of studies have described new and persistent symptoms and conditions as potential post-acute sequelae of SARS-CoV-2 infection (PASC). However, it remains unclear whether certain symptoms or conditions occur more frequently among persons with SARS-CoV-2 infection compared with those never infected with SARS-CoV-2. We compared the occurrence of specific COVID-associated symptoms and conditions as potential PASC 31- to 150-day following a SARS-CoV-2 test among adults and children with positive and negative test results. Methods We conducted a retrospective cohort study using electronic health record (EHR) data from 43 PCORnet sites participating in a national COVID-19 surveillance program. This study included 3,091,580 adults (316,249 SARS-CoV-2 positive; 2,775,331 negative) and 675,643 children (62,131 positive; 613,512 negative) who had a SARS-CoV-2 laboratory test during March 1, 2020-May 31, 2021 documented in their EHR. We used logistic regression to calculate the odds of having a symptom and Cox models to calculate the risk of having a newly diagnosed condition associated with a SARS-CoV-2 positive test. Results After adjustment for baseline covariates, hospitalized adults and children with a positive test had increased odds of being diagnosed with [greater than or equal to] 1 symptom (adults: adjusted odds ratio[aOR], 1.17[95% CI, 1.11-1.23]; children: aOR, 1.18[95% CI, 1.08-1.28]) or shortness of breath (adults: aOR, 1.50[95% CI, 1.38-1.63]; children: aOR, 1.40[95% CI, 1.15-1.70]) 31-150 days following a SARS-CoV-2 test compared with hospitalized individuals with a negative test. Hospitalized adults with a positive test also had increased odds of being diagnosed with [greater than or equal to] 3 symptoms or fatigue compared with those testing negative. The risks of being newly diagnosed with type 1 or type 2 diabetes (adjusted hazard ratio[aHR], 1.25[95% CI, 1.17-1.33]), hematologic disorders (aHR, 1.19[95% CI, 1.11-1.28]), or respiratory disease (aHR, 1.44[95% CI, 1.30-1.60]) were higher among hospitalized adults with a positive test compared with those with a negative test. Non-hospitalized adults with a positive test also had higher odds or increased risk of being diagnosed with certain symptoms or conditions. Conclusions Patients with SARS-CoV-2 infection, especially those who were hospitalized, were at higher risk of being diagnosed with certain symptoms and conditions after acute infection. Keywords: SARS-CoV-2, Long-COVID, Electronic health record, COVID-19 pandemic
Background An increasing number of studies have described new and persistent symptoms and conditions as potential post-acute sequelae of SARS-CoV-2 infection (PASC). However, it remains unclear whether certain symptoms or conditions occur more frequently among persons with SARS-CoV-2 infection compared with those never infected with SARS-CoV-2. We compared the occurrence of specific COVID-associated symptoms and conditions as potential PASC 31- to 150-day following a SARS-CoV-2 test among adults and children with positive and negative test results. Methods We conducted a retrospective cohort study using electronic health record (EHR) data from 43 PCORnet sites participating in a national COVID-19 surveillance program. This study included 3,091,580 adults (316,249 SARS-CoV-2 positive; 2,775,331 negative) and 675,643 children (62,131 positive; 613,512 negative) who had a SARS-CoV-2 laboratory test during March 1, 2020-May 31, 2021 documented in their EHR. We used logistic regression to calculate the odds of having a symptom and Cox models to calculate the risk of having a newly diagnosed condition associated with a SARS-CoV-2 positive test. Results After adjustment for baseline covariates, hospitalized adults and children with a positive test had increased odds of being diagnosed with [greater than or equal to] 1 symptom (adults: adjusted odds ratio[aOR], 1.17[95% CI, 1.11-1.23]; children: aOR, 1.18[95% CI, 1.08-1.28]) or shortness of breath (adults: aOR, 1.50[95% CI, 1.38-1.63]; children: aOR, 1.40[95% CI, 1.15-1.70]) 31-150 days following a SARS-CoV-2 test compared with hospitalized individuals with a negative test. Hospitalized adults with a positive test also had increased odds of being diagnosed with [greater than or equal to] 3 symptoms or fatigue compared with those testing negative. The risks of being newly diagnosed with type 1 or type 2 diabetes (adjusted hazard ratio[aHR], 1.25[95% CI, 1.17-1.33]), hematologic disorders (aHR, 1.19[95% CI, 1.11-1.28]), or respiratory disease (aHR, 1.44[95% CI, 1.30-1.60]) were higher among hospitalized adults with a positive test compared with those with a negative test. Non-hospitalized adults with a positive test also had higher odds or increased risk of being diagnosed with certain symptoms or conditions. Conclusions Patients with SARS-CoV-2 infection, especially those who were hospitalized, were at higher risk of being diagnosed with certain symptoms and conditions after acute infection. Keywords: SARS-CoV-2, Long-COVID, Electronic health record, COVID-19 pandemic