학술논문
Tn7 recognizes transposition target structures associated with DNA replication using the DNA-binding protein TnsE
Document Type
Statistical Data Included
Author
Source
Genes & Development. March 15, 2001, Vol. 15 Issue 6, p737, 11 p.
Subject
Language
ISSN
0890-9369
Abstract
The bacterial transposon Tn7 has been found to recognize transposition target structures associated with DNA replication. Tn7 transposition directed by the transposon-encoded DNA-binding protein TnsE occurs in one orientation relative to chromosomal DNA replication. Mutant TnsE proteins that make higher levels of transposition possible bind DNA better than the wild-type protein. In Escherichia coli, the pattern of TnsE-mediated insertion events around the chromosome sheds some light on how DNA replication forks go forward.