부산대학교 도서관

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1574-6976.2009.00175.x Byline: Sally R. Partridge (1), Guy Tsafnat (2), Enrico Coiera (2), Jonathan R. Iredell (1) Keywords: gene cassette; integron; antibiotic resistance; nomenclature; bioinformatics; computer-aided discovery Abstract: Abstract Gene cassettes are small mobile elements, consisting of little more than a single gene and recombination site, which are captured by larger elements called integrons. Several cassettes may be inserted into the same integron forming a tandem array. The discovery of integrons in the chromosome of many species has led to the identification of thousands of gene cassettes, mostly of unknown function, while integrons associated with transposons and plasmids carry mainly antibiotic resistance genes and constitute an important means of spreading resistance. An updated compilation of gene cassettes found in sequences of such 'mobile resistance integrons' in GenBank was facilitated by a specially developed automated annotation system. At least 130 different ( Author Affiliation: (1)Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Sydney, NSW, Australia (2)Centre for Health Informatics, University of New South Wales, Sydney, NSW, Australia Article History: Received 5 August 2008; revised 17 February 2009; accepted 18 February 2009.Final version published online 15 April 2009. Article note: Correspondence: Sally R. Partridge, CIDM, Level 3, ICPMR Building, Westmead Hospital, NSW 2145, Australia. Tel.: +61 2 9845 6278; fax: +61 2 9891 5317; e-mail: sally.partridge@swahs.health.nsw.gov.au