부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.semcdb.2006.11.012 Byline: Toru Oka, Jian Xu, Jeffery D. Molkentin Keywords: Cardiac hypertrophy; Transcription factors; Cardiomyopathy; Gene expression; Signaling; Chromatin Abstract: A finite number of transcription factors constitute a combinatorial code that orchestrates cardiac development and the specification and differentiation of myocytes. Many, if not all of these same transcription factors are re-employed in the adult heart in response to disease stimuli that promote hypertrophic enlargement and/or dilated cardiomyopathy, as part of the so-called "fetal gene program". This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development. Author Affiliation: Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA