학술논문
Reservoir competence of the redwood chipmunk (Tamias ochrogenys) for Anaplasma phagocytophilum
Document Type
Report
Author
Source
Vector-Borne and Zoonotic Diseases. December 1, 2009, Vol. 9 Issue 6, p573, 5 p.
Subject
Language
English
ISSN
1530-3667
Abstract
Introduction naplasma phagocytophilum, which causes granulocytic anaplasmosis (GA), is an emerging pathogen across the Holarctic in humans, domestic animals, and wildlife (Madigan 1993; Greig et al. 1996; Foley 2000; Foley [...]
Granulocytic anaplasmosis (GA) is an emerging tick-transmitted disease that persists in rodent- Ixodes ricinuscomplex tick cycles across the Holarctic. Although the putative reservoir for anaplasmosis in the western United States is the dusky-footed woodrat (Neotoma fuscipes), this rodent was not shown reservoir-competent because of failure of infection from woodrats to other animals via ticks. Redwood chipmunks are common in habitats where Anclplclsmcl phagocytophilum is common, have high PCR- and seroprevalence, and are infested with a diversity of Ixodes spp. ticks. Experimental infection of seven wild-caught A. phagocytophilum-negative redwood chipmunks induced persistent periods of recurrent rickettsemia during the persistent phase of infection. Of three animals for which xenodiagnosis was attempted, all successfully infected pools of I. pacificus larvae during the primary rickettsemia. We show that chipmunks are reservoir-competent for GA and may be important for maintaining infection in nature. Key Words: disease ecology--Ixodes--sciurid--tick-borne disease. DOI: 10.1089/vbz.2008.0142
Granulocytic anaplasmosis (GA) is an emerging tick-transmitted disease that persists in rodent- Ixodes ricinuscomplex tick cycles across the Holarctic. Although the putative reservoir for anaplasmosis in the western United States is the dusky-footed woodrat (Neotoma fuscipes), this rodent was not shown reservoir-competent because of failure of infection from woodrats to other animals via ticks. Redwood chipmunks are common in habitats where Anclplclsmcl phagocytophilum is common, have high PCR- and seroprevalence, and are infested with a diversity of Ixodes spp. ticks. Experimental infection of seven wild-caught A. phagocytophilum-negative redwood chipmunks induced persistent periods of recurrent rickettsemia during the persistent phase of infection. Of three animals for which xenodiagnosis was attempted, all successfully infected pools of I. pacificus larvae during the primary rickettsemia. We show that chipmunks are reservoir-competent for GA and may be important for maintaining infection in nature. Key Words: disease ecology--Ixodes--sciurid--tick-borne disease. DOI: 10.1089/vbz.2008.0142