학술논문
Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder
Document Type
Report
Author
Source
BMC Psychiatry. September 4, 2020, Vol. 20 Issue 1
Subject
Language
English
ISSN
1471-244X
Abstract
Author(s): Sayo Hamatani[sup.1,2], Aki Tsuchiyagaito[sup.1,3], Masato Nihei[sup.1], Yuta Hayashi[sup.4,5], Tokiko Yoshida[sup.1], Jumpei Takahashi[sup.1], Sho Okawa[sup.5,6], Honami Arai[sup.1], Maki Nagaoka[sup.1], Kazuki Matsumoto[sup.1], Eiji Shimizu[sup.1,4,7] and Yoshiyuki Hirano[sup.1] Background Obsessive-compulsive disorder (OCD) [...]
Background Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT. Methods Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses. Results Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT . Conclusions Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD. Trial registration UMIN, UMIN00024087. Registered 20 September 2016 - Retrospectively registered (including retrospective data). Keywords: Obsessive-compulsive disorder, Exposure and response prevention, Cognitive behavioral therapy, Therapeutic response
Background Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT. Methods Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses. Results Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT . Conclusions Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD. Trial registration UMIN, UMIN00024087. Registered 20 September 2016 - Retrospectively registered (including retrospective data). Keywords: Obsessive-compulsive disorder, Exposure and response prevention, Cognitive behavioral therapy, Therapeutic response