학술논문
A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles
Document Type
Academic Journal
Source
Proceedings of the National Academy of Sciences of the United States. August 1, 1992, Vol. 89 Issue 15, p6891, 5 p. photograph
Subject
Language
ISSN
0027-8424
Abstract
Current knowledge suggests that the replication of kinetoplast DNA (kDNA) of flagellate protozoans involve the recognition of the universal minicircle sequence (UMS) as the origin of replication. To further elucidate this process, the UMS region of Crithidia fasciculata was analyzed. The results showed that C. fasciculata UMS is recognized by a single-stranded DNA-binding protein which binds specifically to the H strand of the UMS.