부산대학교 도서관

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative [CD127.sup.+] [CD161.sup.+] ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. [CRTH2.sup.+] ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for [CRTH2.sup.+] ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 ([T.sub.H]2) cytokines.
Innate lymphoid cells (ILCs) represent an emerging family of cell types that seem to have crucial roles in tissue remodeling and in innate immunity to pathogenic and nonpathogenic microorganisms (1-3). [...]