학술논문
A receptor in pituitary and hypothalamus that functions in growth hormone release
Document Type
Academic Journal
Author
Howard, Andrew D.; Feighner, Scott D.; Cully, Doris F.; Arena, Joseph P.; Liberator, Paul A.; Rosenblum, Charles I.; Hamelin, Michel; Hreniuk, Donna L.; Palyha, Oksana C.; Anderson, Jennifer; Paress, Philip S.; Diaz, Carmen; Chou, Michael; Liu, Ken K.; McKee, Karen Kulju; Pong, Sheng-Shung; Chaung, Lee-Yuh; Elbrecht, Alex; Dashkevicz, Mike; Heavens, Robert; Rigby, Mike; Sirinathsinghji, Dalip J. S.; Dean, Dennis C.; Melillo, David G.; Patchett, Arthur A.; Nargund, Ravi; Griffin, Patrick R.; DeMartino, Julie A.; Gupta, Sunil K.; Schaeffer, James M.; Smith, Roy G.; Van der Ploeg, Lex H.T.
Source
Science. August 16, 1996, Vol. 273 Issue 5277, p974, 4 p.
Subject
Language
English
ISSN
0036-8075
Abstract
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein-coupled receptor (GPCR) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
We sought to correct GH deficiencies by identifying a compound capable of mimicking or amplifying the biological oscillator that regulates GH release. GH secretion is controlled by at least two [...]
We sought to correct GH deficiencies by identifying a compound capable of mimicking or amplifying the biological oscillator that regulates GH release. GH secretion is controlled by at least two [...]