학술논문
Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle
Document Type
Academic Journal
Source
The American Journal of Physiology. April, 1993, Vol. 264 Issue 4, pC932, 12 p.
Subject
Language
ISSN
0002-9513
Abstract
The effect of changes in intracellular pH on calcium regulation was studied using cultured rat aoritc vascular smooth muscle cells. Results showed an increase in cytosolic Ca+ upon rapid rise in pH which was diminished with depletion of sarcoplasmic reticulum stores by vasopressin, uptake blocker or entry inhibitors. An acidic cellular milieu also increased Ca+ release which dspite pretreatment with inhibitors or entry blockers. The increase in Ca+ in acidification was not sensitive to inhibitors and may be due to cellular buffering mechanisms.