부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jpainsymman.2007.03.014 Byline: Adeline Paris (a), Remi Horvath (b), Pierre Basset (c), Stephane Thiery (c), Pascal Couturier (b), Alain Franco (b), Jean-Luc Bosson (a) Abstract: Bedsore and ulcer care can often be painful and no standardized analgesic method exists today for pain relief during treatment in adults and the elderly. To evaluate the analgesic efficacy of a nitrous oxide-oxygen mixture vs. morphine during painful bedsore and ulcer care in adult and elderly patients, we conducted a randomized, crossover, multicenter, prospective, open-label, pilot study. Thirty-four inpatients, aged 53-96 years (median 84 years), were recruited in Grenoble University Hospital, Annecy Hospital and Chambery Hospital, France, from January to June 2001. Each of the 34 patients received morphine (M), nitrous oxide-oxygen mixture (E), or morphine+nitrous oxide-oxygen mixture (ME) during painful care in a crossover protocol. Treatments were changed every two days and the study duration was six days. Analgesia was evaluated before and after each care session using a behavioral scale to evaluate pain in noncommunicating adults (ECPA), a visual analog scale (VAS), a global hetero-evaluation scale (GHES), and the DOLOPLUS-2 scale. There was a significant overall difference (P Author Affiliation: (a) Clinical Research Center, University Hospital of Grenoble, Grenoble (b) Department of Geriatric and Community Medicine, University Hospital of Grenoble, Grenoble (c) Pain and Palliative Care Unit, Chambery Hospital Center, Chambery, France Article History: Accepted 20 March 2007