학술논문
Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melanoma cell line
Document Type
Academic Journal
Author
Source
The Journal of Cell Biology. Feb 24, 1997, Vol. 136 Issue 4, p845, 13 p.
Subject
Language
ISSN
0021-9525
Abstract
The hypothesis that microtubule-associated protein 2 (MAP2c) present in growth cones serves as a mediator between the actin and microtubules was studied. Human melanoma cell, M2, that lacked an actin-binding protein-280 was used to investigate the problem. Vitro rheometry confirmed that MAP2c is an efficient actin gelation protein capable of organizing actin filaments into an isotropic array at very low concentrations. MAP2c was concluded to mediate functionally specific interactions between microfilaments and microtubules.