부산대학교 도서관

Background Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been implemented as a standard treatment strategy in locally advanced rectal cancer (LARC). However, there is a wide spectrum of response to nCRT. The aim of this study was to determine whether enhancer of zeste homologue 2 (EZH2 ) expression could predict response to nCRT and outcomes for patients in LARC. Method The study examined the EZH2 expression in 112 biopsies by immohistochemistry. The associations between EZH2 and clinical characters were analyzed. Results EZH2 expression in biopsy tissue was significantly related to increased tumor cell proliferation, as assessed by Ki-67 expression with a cutoff value of 37% (p Conclusion Our study revealed that low EZH2 expression in biopsy tissue might be a useful predictive factor of good tumor response to nCRT and longer 5-year DFS in patients with LARC. However this is a relatively small retrospective study, to further validate the role of EZH2 in rectal cancer, large consistent cohort studies are needed. Keywords: Rectal cancer, EZH2, Neoadjuvant chemoradiotherapy, Tumor response, Prognosis
Author(s): Xiangjiao Meng[sup.1] , Zhaoqin Huang[sup.2] , Renben Wang[sup.1] , Yuhong Jiao[sup.1] , Huijuan Li[sup.3] , Xiaoqing Xu[sup.1] , Rui Feng[sup.1] , Kunli Zhu[sup.1] , Shumei Jiang[sup.1] , Hongjiang Yan[sup.1] [...]