부산대학교 도서관

Prothymosin [alpha] (ProT[alpha]) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProT[alpha] expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProT[alpha]-positive lung cancer. Immunohistochemical staining of ProT[alpha] was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProT[alpha] and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProT[alpha]-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProT[alpha]-positive by scoring index. The majority of patients with ProT[alpha]-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P
Introduction Prothymosin [alpha] (ProT[alpha]) is a 12.5 kDa acidic nuclear protein, initially isolated from rat thymus as the putative precursor of thymosin [alpha]1, and is regarded as a thymic immunoregulatory [...]