부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jpedsurg.2009.04.013 Byline: Amy E. Lovejoy (a), Ruth A. Bush (b), Alice L. Pong (c), Mary L. Hilfiker (b) Keywords: Factor V Leiden; Thrombosis; Inferior vena cava; Trauma Abstract: The epidemiology of deep vein thrombosis in adolescents has 2 potential associations. First, there is a demonstrated association with a congenital anomaly of the inferior vena cava (Dean SM, Tytle TL. Vas Med. 2006;11:165-169; Schnieider JG, Eynatten MV, Dugi KA, et al. J Intern Med. 2002;252:276-280). Secondly, resistance to activated protein C as a result of factor V Leiden is associated with thromboembolic disease at an early age (Price DT, Ridker PM. Ann Intern Med. 1997;127:895-903). Imaging modalities, central venous catheters, and improved life expectancy for critically and chronically ill children have resulted in an increased diagnosis of thromboembolic disease in the pediatric population (Journeycake MM, Manco-Johnson MJ. Hematol Oncol Clin N Am. 2004;18;1315-1338), and evaluation for thrombophilia should be performed for any child with thromboembolic disease. Author Affiliation: (a) Division of Hematology/Oncology, Rady Children's Hospital, San Diego, CA 92123, USA (b) Department of Trauma, Rady Children's Hospital, San Diego, CA 92123, USA (c) Department of Infectious Disease, Rady Children's Hospital, San Diego, CA 92123, USA Article History: Received 20 November 2008; Revised 2 April 2009; Accepted 4 April 2009