학술논문
Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination
Document Type
Academic Journal
Source
Journals of Gerontology. Nov, 1993, Vol. 48 Issue 6, pB231, 6 p.
Subject
Language
ISSN
0022-1422
Abstract
Tetanus toxoid (TT) antigen-induced anti-tetanus toxoid antibody (anti-TT) synthesis in older and younger rats is comparatively analyzed for characterization of humoral immunity responses in elder populations. Lymphocytes isolated from older rats exhibit a low yield of anti-TT product in contrast to anti-TT synthesized in lymphocytes of younger rats. Attenuation of anti-TT synthesis in older rats is ascribed to a reduced number of B cells releasing the anti-TT immunoglobin (IgG) which renders a decline in the average levels of anti-TT IgG synthesized per TT-selective B cell. Serum titers in immunized young rats is markedly enhanced, while that in older rats exhibits a decline.